Oramet-SR 500 mg (Tablet (Sustained Release))
Unit Price: ৳ 6.00 (5 x 10: ৳ 300.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Drug international ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of diabetes in overweight patients
- Reduction of diabetic complications
- Monotherapy for adults
- Combination therapy for adults
- Treatment for children from 10 years of age
- Monotherapy for children and adolescents
- Combination therapy for children and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Different mechanism of action from sulfonylureas
- No production of hypoglycemia
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Improves insulin sensitivity
- Increases peripheral glucose uptake and utilization
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Starting dose for adults and children
- Dosage increases
- Maximum daily dose for additional glycemic control
- Instructions for Metformin immediate release tablet
- Instructions for Metformin extended release tablet
- Dosage adjustment for renal impaired patients
Interaction
- No chronic co-administration information with Furosemide
- Enhanced absorption with Nifedipine
- Minimal effects on Nifedipine
- Potential interaction with cationic drugs
- No effect on Cimetidine pharmacokinetics
- Drugs that may produce hyperglycemia and loss of glycemic control
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Peripheral neuropathy in patients with vitamin B12 deficiency
- Taste disturbance
- Encephalopathy
- Gastrointestinal disorders
- Liver function test abnormalities or hepatitis
- Skin reactions
Pregnancy & Lactation
- Risk of congenital abnormalities and perinatal mortality
- Recommendation to use insulin during pregnancy
- Excretion into human breast milk
- Limited data on breastfeeding recommendation
Precautions & Warnings
- Substantial excretion by the kidney
- Increased risk of lactic acidosis
- Lower vitamin B12 level
- Increased risk of hypoglycemia
- Monitoring of renal function
- Therapy cessation before surgery and clinical investigations
- Caution in dehydrated patients or those with serious infections
- Regular estimation of Vitamin B-12 levels
- Blood glucose monitoring during combined therapy
- Renal clearance reduction during cimetidine therapy
- Possibility of interaction with anticoagulants
Use in Special Populations
- Dosage adjustment for elderly subjects
- Confirmation of type 2 diabetes mellitus before treatment initiation
- No effect on growth and puberty detected during controlled clinical studies
- Caution in prescribing to children aged between 10 and 12 years
- Creatinine clearance determination before treatment initiation and regularly thereafter
- Caution in situations where renal function may become impaired
- Contradictions in patients with GFR < 30 ml/min
Overdose Effects
- No hypoglycemia seen with Oramet-SR doses
- Occurrence of lactic acidosis
- Medical emergency requiring hospital treatment
- Hemodialysis for removal of lactate and Oramet-SR
Therapeutic Class
- Biguanides
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children