Oramet-SR 1000 mg (Tablet (Sustained Release))
Unit Price: ৳ 9.00 (6 x 5: ৳ 270.00)
Strip Price: ৳ 45.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | Drug international ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus in overweight adults
- Treatment of type 2 diabetes mellitus in children from 10 years of age and adolescents
- Reduction of diabetic complications in overweight patients
- Monotherapy for type 2 diabetes mellitus
- Combination therapy with other oral antidiabetic agents or insulin
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Maximum recommended daily doses
- Starting dose and titration for adults and children
- Different dosages for immediate release and extended release tablets
- Guidelines for renal impaired patients
Interaction
- Interaction with Furosemide and Nifedipine
- Potential interaction with cationic drugs and renal tubular transport systems
- Effects on Cimetidine pharmacokinetics
- Drugs that may produce hyperglycemia
Contraindications
- Hypersensitivity to the active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Acute conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decreased vitamin B12 absorption
- Peripheral neuropathy
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
- Excretion into human breast milk
- Adverse effects on breastfed newborns/infants
- Recommendation against breastfeeding during metformin treatment
Precautions & Warnings
- Substantial excretion by the kidney
- Lowering of vitamin B12 level
- Increased risk of hypoglycemia
- Recommended monitoring of renal function
- Temporary discontinuation in certain clinical investigations
- Caution in dehydration, serious infections, and trauma
Use in Special Populations
- Dosage adjustment for elderly subjects
- No effect on growth and puberty in controlled clinical studies
- Special caution in prescribing to children aged 10-12 years
- Regular assessment of renal function
- Adjustment of therapy in elderly subjects with decreased renal function
Overdose Effects
- Lactic acidosis as a medical emergency
- Treatment with hemodialysis
Therapeutic Class
- Biguanides
Storage Conditions
- Below 30°C temperature
- Protected from light & moisture
- Keep out of reach of children