Sugamet 500 mg (Tablet)
Unit Price: ৳ 4.00 (10 x 10: ৳ 400.00)
Strip Price: ৳ 40.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Metformin hydrochloride |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of type 2 diabetes mellitus
- Management of type 2 diabetes in overweight patients
- Monotherapy for adults with type 2 diabetes
- Combination therapy for adults with type 2 diabetes
- Combination therapy for children from 10 years of age and adolescents
Pharmacology
- Biguanide type oral antihyperglycemic drug
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
- Decreases intestinal absorption of glucose
Dosage & Administration
- Individualized dosage based on effectiveness and tolerance
- Different dosages for immediate release and extended release tablets
- Dosage adjustments for adults and children
- Guidelines for renal impaired patients
- Instructions for swallowing extended release tablet
Interaction
- No chronic interaction with Furosemide
- Enhancement of absorption by Nifedipine
- Potential interaction with cationic drugs through renal tubular transport systems
- No effect on Cimetidine pharmacokinetics
- Drugs that may produce hyperglycemia
Contraindications
- Hypersensitivity to active substance or excipients
- Acute metabolic acidosis
- Severe renal failure
- Conditions altering renal function
- Conditions causing tissue hypoxia
Side Effects
- Hemolytic anemia
- Lactic acidosis
- Decrease of vitamin B12 absorption
- Taste disturbance
- Gastrointestinal disorders
- Liver function test abnormalities
- Skin reactions
Pregnancy & Lactation
- Risk of congenital abnormalities and perinatal mortality
- Recommendation for insulin use during pregnancy
- Excretion into human breast milk
- Limited data on breastfeeding
Precautions & Warnings
- Substantial excretion by the kidney
- Lowering of vitamin B12 level
- Risk of hypoglycemia
- Regular monitoring of renal function
- Discontinuation before surgery
- Advice against use in conditions causing dehydration or serious infections
Use in Special Populations
- Dosage adjustment for elderly subjects
- Confirmation of type 2 diabetes mellitus before treatment in pediatric population
- No effect on growth and puberty detected
- Caution in prescribing to children aged between 10 and 12 years
- Regular assessment of renal function
Overdose Effects
- No hypoglycemia observed in high doses
- Occurrence of lactic acidosis
- Emergency treatment in hospital
- Hemodialysis as the most effective removal method
Therapeutic Class
- Biguanides
Storage Conditions
- Below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children