Sixtin 5 mg (Tablet)

Indications

• Adjunct to diet and exercise
• Improves glycemic control
• Type 2 diabetes mellitus

Limitation Of Use

• Not for type 1 diabetes mellitus
• Not for diabetic ketoacidosis

Pharmacology

• Inhibits dipeptidyl peptidase IV (DPP-IV) enzyme
• Elevates incretin levels
• Stimulates insulin secretion
• Improves glycaemic control

Dosage

• Recommended dosage of 2.5 mg or 5 mg once daily
• No dosage adjustment for mild renal impairment
• Dosage of 2.5 mg for moderate or severe renal impairment or with end-stage renal disease
• Dosage adjustment with concomitant use of strong CYP3A4/5 inhibitors
• Lower dose required when used with insulin secretagogue or insulin

Administration

• May be taken with or without food

Interaction

• Increased risk of hypoglycaemia with concomitant sulfonylureas
• Increased serum levels with CYP3A4/5 inhibitors
• Reduced effect with CYP3A4 inducers

Contraindications

• Type 1 diabetes
• Diabetic ketoacidosis

Side Effects

• Pancreatitis
• Heart Failure
• Hypoglycemia
• Hypersensitivity Reactions
• Arthralgia
• Bullous pemphigoid

Pregnancy & Lactation

• Category B

Precautions & Warnings

• Moderate and severe renal impairment
• Pregnancy and lactation

Use in Special Populations

• No dosage adjustment needed for mild renal impairment
• 2.5 mg once daily for moderate to severe impairment including with ESRD requiring hemodialysis
• No dosage adjustment for hepatic impairment

Therapeutic Class

• Dipeptidyl Peptidase-4 (DPP-4) inhibitor

Storage Conditions

• Store between 20-25°C

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