Sigtil 50 mg (Tablet)

Unit Price: ৳ 15.00 (30's pack: ৳ 450.00)

Medicine Details

Category Details
Generic Sitagliptin
Company The white horse pharmaceuticals ltd
Also available as
Sigtil 25 mg tablet Sigtil 100 mg tablet

Indications

  • Monotherapy and Combination Therapy
  • Adjunct to diet and exercise
  • Improve glycemic control in adults with type 2 diabetes mellitus

Pharmacology

  • DPP-4 inhibitor
  • Slows inactivation of incretin hormones
  • Increases and prolongs action of incretin hormones
  • Regulates glucose homeostasis
  • Increases insulin release
  • Decreases glucagon levels
  • Selectivity for DPP-4
  • Does not inhibit DPP-8 or DPP-9 activity

Dosage & Administration

  • Recommended dose of 50 mg twice a day or 100 mg once daily
  • Can be taken with or without food

Interaction

  • Did not meaningfully alter the pharmacokinetics of certain drugs
  • Slightly increases the mean concentration of Digoxin

Contraindications

  • History of serious hypersensitivity reaction to sitagliptin

Side Effects

  • Common adverse reactions include headache, upper respiratory tract infection, and nasopharyngitis
  • Hypoglycemia may occur in patients treated with the combination of Sigtil and sulfonylurea, and add on to insulin

Pregnancy & Lactation

  • Pregnancy Category B
  • Secreted in the milk of lactating rats
  • Caution advised when administered to nursing women

Precautions & Warnings

  • Discontinue if pancreatitis is suspected
  • Dosage adjustment recommended in patients with renal insufficiency
  • Use with medications known to cause hypoglycemia may require dosage adjustment of sulfonylurea or insulin
  • Hypersensitivity reactions reported
  • Safety and effectiveness not established in pediatric patients under 18 years of age
  • Careful dose selection and renal function assessment advised for elderly patients

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients under 18 years of age
  • Careful dose selection and renal function assessment advised for elderly patients

Overdose Effects

  • Maximal mean increases in QTc observed
  • No experience with doses above 800 mg in clinical studies
  • Appropriate supportive measures in the event of overdose
  • Modestly dialyzable

Therapeutic Class

Dipeptidyl Peptidase-4 (DPP-4) inhibitor

Storage Conditions

Store below 25°C in a dry place away from light, out of the reach of children, and not later than the date of expiry. To be dispensed only on the prescription of a registered physician

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