Incrit 50 mg (Tablet)

Unit Price: ৳ 18.05 (2 x 10: ৳ 361.00)
Strip Price: ৳ 180.50

Medicine Details

Category Details
Generic Sitagliptin
Company Synovia pharma plc
Also available as
Incrit 100 mg tablet

Indications

  • Adjunct to diet and exercise for type 2 diabetes mellitus
  • Monotherapy and combination therapy
  • Improves glycemic control
  • Not for type 1 diabetes
  • Not for diabetic ketoacidosis
  • Not studied in patients with a history of pancreatitis

Pharmacology

  • DPP-4 inhibitor
  • Slows inactivation of incretin hormones
  • Increases and prolongs action of incretin hormones
  • Regulates glucose homeostasis
  • Increases insulin release
  • Decreases glucagon levels
  • Selectivity for DPP-4

Dosage & Administration

  • Recommended dose of 50mg twice a day or 100mg once daily
  • Can be taken with or without food

Interaction

  • Did not alter pharmacokinetics of certain drugs
  • Slightly increases digoxin concentration

Contraindications

  • History of serious hypersensitivity reaction to sitagliptin

Side Effects

  • Common adverse reactions include headache, upper respiratory tract infection, and nasopharyngitis
  • Hypoglycemia may occur in patients treated with combination therapy

Pregnancy & Lactation

  • Pregnancy Category B
  • Should be used during pregnancy only if clearly needed
  • Caution should be exercised when administered to a nursing woman

Precautions & Warnings

  • Prompt discontinuation if pancreatitis is suspected
  • Dosage adjustment in patients with renal insufficiency
  • Caution when used with medications known to cause hypoglycemia
  • Reports of serious hypersensitivity reactions
  • Safety and effectiveness in pediatric patients not established
  • Careful dose selection in elderly with decreased renal function

Use in Special Populations

  • Safety and effectiveness in pediatric patients under 18 years not established
  • Caution and dose adjustments in elderly with decreased renal function

Overdose Effects

  • Maximal mean increases in QTc of 8.0 msec observed at high doses
  • Usual supportive measures recommended in the event of an overdose
  • Modestly dialyzable

Therapeutic Class

  • Dipeptidyl Peptidase-4 (DPP-4) inhibitor

Storage Conditions

  • Store below 25°C in a dry place away from light
  • Keep out of the reach of children
  • Do not use after expiry date
  • To be dispensed only on prescription of a registered physician

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