Glimet 1 mg (Tablet)

Unit Price: ৳ 3.00 (5 x 10: ৳ 150.00)
Strip Price: ৳ 30.00

Medicine Details

Category Details
Generic Repaglinide
Company Drug international ltd

Title and Categories

  • Glimet
  • Medicine
  • Type 2 Diabetes Treatment
  • Oral Blood-Glucose-Lowering Drug
  • Meglitinide Class

Color Options

  • N/A

Dimensions

  • N/A

Functions

  • Lowers Blood Glucose
  • Stimulates Insulin Secretion
  • Manages Type 2 Diabetes Mellitus
  • Adjunct to Diet and Exercise

Materials

  • N/A

Technical Specifications

  • Rapid Onset of Action
  • Rapid Elimination
  • Binds to Specific Receptors in Cell Membrane
  • Causes Pancreas to Release More Insulin
  • Closure of ATP Dependent K+ Channels
  • Depolarisation of Cell Membrane

Design Elements

  • Oral Dosage Form
  • Immediate or Up to 30 Minutes Before Each Meal

Usability Features

  • Dosage Adjustment According to Response at Intervals of 1-2 Weeks
  • Maximum 16 mg Daily
  • Administration with Meals
  • Storage Below 30°C
  • Keep Away from Light

Indications

  • Lowering Blood Glucose in Type 2 Diabetes Mellitus Patients
  • Adjunct to Diet and Exercise

Description

  • An Oral Blood-Glucose-Lowering Drug of the Meglitinide Class
  • Works by Causing Pancreas to Release More Insulin into the Blood Stream

Pharmacology

  • Binds to Specific Receptors in the Cell Membrane
  • Closure of ATP Dependent K+ Channels
  • Depolarisation of Cell Membrane
  • Leads to Ca++ Influx
  • Increased Intracellular Ca++
  • Stimulation of Insulin Secretion

Dosage & Administration

  • Starting Dose 0.5 mg for Patients Not Previously Treated or HbA1c < 8%
  • Initial Dose 1 or 2 mg for Patients Previously Treated with Blood Glucose-Lowering Drugs and HbA1c > 8%
  • Dosage Adjustment According to Response at Intervals of 1-2 Weeks
  • Maximum 16 mg Daily
  • Taken Immediately or Up to 30 Minutes Before Each Meal

Interaction

  • Possible Interactions with Inhibitors of the Cytochrome P450 Enzyme System (Azole Antifungals and Macrolides)
  • Possible Interactions with Inducers of the Cytochrome P450 Enzyme System (Rifampin, Phenobarbital, Carbamazepine, Troglitazone, etc.)
  • Cimetidine Has No Significant Effect on Glimet Absorption or Clearance
  • No Significant Effect of Glimet on Digoxin, Theophylline, or Warfarin
  • Increased Risk of Hypoglycemia When Co-administered with Highly Protein Bound Drugs (e.g., NSAIDs)
  • Increased Risk of Hypoglycemia When Co-administered with Certain Drugs such as Salicylates, Sulphonamides, Chloramphenicol, Coumarins, Probenecid, Monoamine Oxidase (MAO) Inhibitors, and Adrenergic Blockers

Contraindications

  • Diabetic Ketoacidosis
  • Type 1 Diabetes Mellitus
  • Known Hypersensitivity to the Drug or its Inactive Ingredients

Side Effects

  • Hypoglycemia and Related Symptoms
  • Upper Respiratory Tract Infections
  • Diarrhea
  • Constipation
  • Nausea and Vomiting
  • Hypersensitivity Reactions such as Rashes and Urticaria

Pregnancy & Lactation

  • Safety not Established in Pregnant Women
  • Use During Pregnancy only if Clearly Needed
  • Unknown Excretion in Human Milk
  • Consideration for Discontinuation of Nursing or the Drug

Precautions & Warnings

  • Substitution of Insulin during Concurrent Illness and Surgery
  • Capable of Producing Hypoglycemia
  • Administered with Meals to Lessen the Risk of Hypoglycemia

Overdose Effects

  • Lowering of Blood Glucose
  • Severe Hypoglycemic Reactions with Coma, Seizure, or Other Neurological Impairment Infrequently Occur

Therapeutic Class

  • Meglitinide Analogues

Storage Conditions

  • Do not Store Above 30°C
  • Keep Away from Light
  • Keep Out of the Reach of Children

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