Gluretor 1 mg (Tablet)

Unit Price: ৳ 4.00 (3 x 10: ৳ 120.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Repaglinide
Company Pacific pharmaceuticals ltd
Also available as
Gluretor 05 mg tablet Gluretor 2 mg tablet

Indications

  • Lowering blood glucose in patients with type 2 diabetes mellitus
  • Adjunct to diet and exercise for controlling hyperglycemia
  • Use in combination with Metformin for lowering blood glucose

Description

  • Oral blood-glucose-lowering drug of the meglitinide class

Pharmacology

  • Binds to specific receptors in the cell membrane
  • Leads to closure of ATP dependent K⁺ channels
  • Stimulates insulin secretion

Dosage & Administration

  • Starting dose of 0.5 mg for patients not previously treated
  • Initial dose of 1 or 2 mg for patients previously treated
  • Should be taken immediately or up to 30 minutes before each meal
  • Dosage adjustment according to response
  • Maximum 16 mg daily

Interaction

  • Possible interactions with cytochrome P450 enzyme system inhibitors
  • Possible interactions with cytochrome P450 enzyme system inducers
  • Cimetidine has no significant effect on absorption or clearance
  • No significant effect on Digoxin, Theophyllin, or Warfarin
  • Possible increase in risk of hypoglycemia with co-administration of NSAIDs
  • Risk of hypoglycemia may be increased with certain drugs such as salicylates

Contraindications

  • Diabetic ketoacidosis, with or without coma
  • Type 1 diabetes mellitus
  • Known hypersensitivity to the drug or its inactive ingredients

Side Effects

  • Hypoglycemia and related symptoms
  • Upper respiratory tract infections
  • Diarrhea
  • Constipation
  • Nausea and vomiting
  • Hypersensitivity reactions like rashes and urticaria

Pregnancy & Lactation

  • Safety in pregnant women not established
  • Use during pregnancy only if clearly needed
  • Unknown excretion in human milk
  • Decision should be made regarding nursing or discontinuation of the drug

Precautions & Warnings

  • Insulin substitution during concurrent illness and surgery
  • Capable of producing hypoglycemia
  • Administration with meals to reduce risk of hypoglycemia

Overdose Effects

  • Few adverse effects other than lowering of blood glucose with high doses
  • Severe hypoglycemic reactions occur infrequently

Therapeutic Class

  • Meglitinide Analogues

Storage Conditions

  • Do not store above 30°C
  • Keep away from light and out of reach of children

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