Nomopil 0.5 mg (Tablet)

Unit Price: ৳ 2.00 (10 x 10: ৳ 200.00)
Strip Price: ৳ 20.00

Medicine Details

Category Details
Generic Repaglinide
Company Incepta pharmaceuticals ltd
Also available as
Nomopil 1 mg tablet Nomopil 2 mg tablet

Indications

  • Lowering blood glucose in patients with type 2 diabetes mellitus
  • Use in combination with Metformin for lowering blood glucose
  • Adjunct to diet and exercise

Description

  • Oral blood-glucose-lowering drug
  • Belongs to the meglitinide class
  • Works by causing pancreas to release more insulin into the bloodstream
  • Rapid onset of action and elimination

Pharmacology

  • Binds to specific receptors in the cell membrane
  • Leads to closure of ATP dependent K+ channels
  • Depolarization of cell membrane
  • Ca++ influx
  • Increased intracellular Ca++
  • Stimulation of insulin secretion

Dosage & Administration

  • Starting dose based on HbA1c levels
  • Should be taken before each meal
  • Dosage adjustment according to response
  • Maximum dosage of 16 mg daily

Interaction

  • Possible interactions with other medications
  • Inhibitors and inducers of the cytochrome P450 enzyme system
  • Effect on the absorption or clearance of certain drugs
  • Risks of hypoglycemia when co-administered with certain drugs

Contraindications

  • Diabetic ketoacidosis
  • Type 1 diabetes mellitus
  • Known hypersensitivity to the drug or its inactive ingredients

Side Effects

  • Hypoglycemia and related symptoms
  • Upper respiratory tract infections
  • Diarrhea
  • Constipation
  • Nausea and vomiting
  • Hypersensitivity reactions such as rashes and urticaria

Pregnancy & Lactation

  • Safety not established in pregnant women
  • Use during pregnancy only if clearly needed
  • Unknown excretion in human milk
  • Consideration for discontinuing nursing or the drug

Precautions & Warnings

  • Substitution of insulin during concurrent illness or surgery
  • All oral blood glucose-lowering drugs capable of producing hypoglycemia
  • Administration with meals to lessen the risk of hypoglycemia

Overdose Effects

  • Few adverse effects with doses up to 80 mg
  • Hypoglycemic reactions with coma, seizure, or neurological impairment

Therapeutic Class

  • Meglitinide Analogues

Storage Conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of the reach of children

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