Nomopil 2 mg (Tablet)
Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Repaglinide |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for lowering blood glucose in patients with type 2 diabetes mellitus
- Use in combination with Metformin to lower blood glucose
- For patients with hyperglycemia not controlled by diet and exercise alone
Description
- Oral blood-glucose-lowering drug of the meglitinide class
- Works by causing pancreas to release more insulin into the bloodstream
- Rapid onset of action and rapid elimination
Pharmacology
- Binds to specific receptors in the cell membrane
- Leads to the closure of ATP dependent K+ channels
- Depolarisation of cell membrane
- Ca++ influx and increased intracellular Ca++
- Stimulation of insulin secretion
Dosage & Administration
- Starting dose of 0.5 mg for certain patients
- Initial dose of 1 or 2 mg for previously treated patients
- Taken immediately or up to 30 minutes before each meal
- Dosage should be adjusted according to response at intervals of 1-2 weeks
- Maximum 16 mg daily
Interaction
- May need dosage adjustment when taken with other medications
- Possible interactions with inhibitors or inducers of the cytochrome P450 enzyme system
- Interaction with Cimetidine, Digoxin, Theophyllin, Warfarin, NSAIDs, salicylates, sulphonamides, Chloramphenicol, coumarins, Probenecid, monoamine oxidase (MAO) inhibitors, adrenergic blockers
Contraindications
- Diabetic ketoacidosis
- Type 1 diabetes mellitus
- Known hypersensitivity to the drug or its inactive ingredients
Side Effects
- Hypoglycemia and related symptoms
- Upper respiratory tract infections
- Diarrhea
- Constipation
- Nausea and vomiting
- Hypersensitivity reactions like rashes and urticaria
Pregnancy & Lactation
- Safety in pregnant women not established
- Use during pregnancy only if clearly needed
- Not known whether it is excreted in human milk
- Decision should be made whether to discontinue nursing or the drug
Precautions & Warnings
- Insulin should be substituted during concurrent illness and surgery
- Capable of producing hypoglycemia
- Administered with meals to lessen the risk of hypoglycemia
Overdose Effects
- Patients receiving up to 80 mg developed few adverse effects other than lowering of blood glucose
- Severe hypoglycemic reactions with coma, seizure or other neurological impairment occur infrequently
Therapeutic Class
- Meglitinide Analogues
Storage Conditions
- Do not store above 30°C
- Keep away from light and out of the reach of children