Premil 0.5 mg (Tablet)
Unit Price: ৳ 1.94 (31 x 1: ৳ 60.00)
Strip Price: ৳ 1.94
Medicine Details
| Category | Details |
|---|---|
| Generic | Repaglinide |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- adjunct to diet and exercise
- lowering blood glucose
- type 2 diabetes mellitus
- hyperglycemia control
- combination with Metformin
Description
- oral blood-glucose-lowering drug
- meglitinide class
- Type 2 diabetes mellitus
- pancreas insulin release
- rapid onset of action
Mode of Action
- binds to specific receptors
- cell membrane closure
- ATP dependent K channels
- depolarisation of cell membrane
- Ca++ influx
- insulin secretion stimulation
Dosage & Administration
- starting dose
- HbA1c monitoring
- immediate or 30 minutes before meal
- dose adjustment at intervals
- maximum daily dose
Interaction
- cytochrome P450 enzyme system inhibitors
- cytochrome P450 enzyme system inducers
- Cimetidine effect
- interaction with highly protein bound drugs
- risk of hypoglycemia with other medications
Contraindications
- diabetic ketoacidosis
- type 1 diabetes mellitus
- hypersensitivity to the drug or its inactive ingredients
Side Effects
- hypoglycemia
- upper respiratory tract infections
- diarrhea
- constipation
- nausea
- vomiting
- hypersensitivity reactions
- rashes
- urticaria
Pregnancy & Lactation
- safety in pregnant women
- use during pregnancy
- excretion in human milk
- potential adverse reactions in nursing infants
- discontinuation decision
Precautions & Warnings
- substitution during concurrent illness
- insulin administration
- oral blood glucose-lowering drugs capable of producing hypoglycemia
- administration with meals
Overdose Effects
- adverse effects
- lowering of blood glucose
- severe hypoglycemic reactions
- coma
- seizure
- other neurological impairment
Therapeutic Class
- Meglitinide Analogues
Storage Conditions
- do not store above 30°C
- keep away from light
- keep out of reach of children