Premil 2 mg (Tablet)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Repaglinide |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for lowering blood glucose in type 2 diabetes mellitus
- Combination use with Metformin for lowering blood glucose
- Patients with hyperglycemia not controlled by diet and exercise alone
Description
- Oral blood-glucose-lowering drug
- Meglitinide class
- Rapid onset of action and rapid elimination
- Manages Type 2 diabetes mellitus (NIDDM)
Pharmacology
- Binds to specific receptors in cell membrane
- Causes closure of ATP dependent K channels
- Stimulates insulin secretion
- Leads to increased intracellular Ca
Dosage & Administration
- Starting dose for patients not previously treated or HbA1c < 8%: 0.5 mg before each meal
- Initial dose for patients previously treated with HbA1c > 8%: 1 or 2 mg before each meal
- Taken immediately or up to 30 minutes before each meal
- Dosage adjusted according to response; maximum 16 mg daily
Interaction
- Possible interactions with azole antifungals and macrolides
- Accelerated metabolism with Rifampin, Phenobarbital, Carbamazepine, Troglitazone
- No significant effect on Cimetidine, Digoxin, Theophyllin, or Warfarin
- Increased plasma level with NSAIDs, leading to potential hypoglycaemia risk
- Increased risk of hypoglycaemia when co-administered with certain drugs like salicylates, MAO inhibitors, and adrenergic blockers
Contraindications
- Diabetic ketoacidosis
- Type 1 diabetes mellitus
- Known hypersensitivity to the drug or its inactive ingredients
Side Effects
- Hypoglycemia and related symptoms
- Upper respiratory tract infections
- Diarrhea, constipation, nausea, vomiting
- Hypersensitivity reactions like rashes and urticaria
Pregnancy & Lactation
- Safety not established in pregnant women
- Use during pregnancy only if clearly needed
- Unknown excretion in human milk
Precautions & Warnings
- Substitute with insulin during concurrent illness and surgery
- Capable of producing hypoglycemia
- Administered with meals to reduce the risk of hypoglycemia
Overdose Effects
- Severe hypoglycemic reactions infrequent
- Few adverse effects at high doses up to 80 mg
- Hypoglycemia did not occur with meals given at high doses
Therapeutic Class
- Meglitinide Analogues
Storage Conditions
- Do not store above 30°C
- Keep away from light
- Keep out of the reach of children