Dianorm 1 mg (Tablet)

Unit Price: ৳ 3.75 (30's pack: ৳ 112.50)

Medicine Details

Category Details
Generic Repaglinide
Company Rephco pharmaceuticals ltd

Title

  • Dianorm Oral Blood Glucose-Lowering Drug

Categories

  • Medicine
  • Health
  • Diabetes Management

Description

  • Oral blood-glucose-lowering drug of the meglitinide class
  • Used in the management of Type 2 diabetes mellitus (NIDDM)
  • Causes pancreas to release more insulin into the blood stream
  • Rapid onset of action and rapid elimination

Indications

  • Adjunct to diet and exercise to lower blood glucose in patients with type 2 diabetes mellitus (NIDDM)
  • Can be used in combination with Metformin to lower blood glucose

Dosage & Administration

  • Starting dose of 0.5 mg before each meal for patients not previously treated or whose HbA1c < 8%
  • Initial dose of 1 or 2 mg before each meal for patients previously treated with blood glucose-lowering drugs and whose HbA1c > 8%
  • Should be taken immediately or up to 30 minutes before each meal
  • Dosage should be adjusted according to response at intervals of 1-2 weeks; up to 4 mg may be given as a single dose, maximum 16 mg daily

Pharmacology

  • Binds to specific receptors in the cell membrane leading to the closure of ATP dependent K<sup>+</sup> channels and the depolarisation of cell membrane
  • Leads to Ca<sup>++</sup> influx, increased intracellular Ca<sup>++</sup> and the stimulation of insulin secretion

Interaction

  • May need dosage adjustment if taken with other medications
  • Possible interactions with inhibitors and inducers of the cytochrome P450 enzyme system
  • Cimetidine has no significant effect on absorption or clearance
  • No significant effect on Digoxin, Theophyllin, or Warfarin
  • Potential risk of hypoglycaemia when co-administered with certain drugs such as salicylates, sulphonamides, Chloramphenicol, coumarins, Probenecid, monoamine oxidase (MAO) inhibitors, and adrenergic blockers

Contraindications

  • Diabetic ketoacidosis, with or without coma
  • Type 1 diabetes mellitus
  • Known hypersensitivity to the drug or its inactive ingredients

Side Effects

  • Common side effects include hypoglycemia and related symptoms, upper respiratory tract infections, diarrhea, constipation, nausea, vomiting, rashes, and urticaria

Pregnancy & Lactation

  • Safety in pregnant women has not been established
  • Should be used during pregnancy only if clearly needed
  • It is not known whether Repaglinide is excreted in human milk
  • A decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother

Precautions & Warnings

  • Insulin should be substituted during concurrent illness and during surgery
  • All oral blood glucose-lowering drugs are capable of producing hypoglycemia
  • Should be administered with meals to lessen the risk of hypoglycemia

Overdose Effects

  • Patients receiving high doses developed few adverse effects other than lowering of blood glucose
  • Severe hypoglycemic reactions with coma, seizure or other neurological impairment occur infrequently

Therapeutic Class

  • Meglitinide Analogues

Storage Conditions

  • Do not store above 30°C
  • Keep away from light and out of the reach of children

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