Dieta Plus 30 mg+2 mg (Tablet)

Title

• Pioglitazone & Glimepiride Tablet

Categories

• Medicine
• Pharmaceutical

Description

• Combination therapy for type 2 diabetes
• Oral hypoglycemic preparations

Indications

• Adjunct to diet and exercise
• Improves glycemic control
• Type 2 diabetes treatment

Pharmacology

• Insulin-sensitizing agent
• Enhances peripheral glucose utilization
• Selective agonist for peroxisome proliferator-activated receptor-gamma (PPARγ)
• Stimulates insulin release from pancreatic beta cells
• Increases sensitivity of peripheral tissues to insulin

Dosage & Administration

• Once daily administration
• Based on current regimen
• Careful monitoring during dose adjustment

Interaction

• Potential interaction with thiazides, corticosteroids, oral contraceptives, phenytoin, and others
• Metabolism by cytochrome P450 2C9

Contraindications

• Hypersensitivity to pioglitazone or glimepiride
• Diabetic ketoacidosis

Side Effects

• Common adverse experiences include upper respiratory tract infection, injury, headache, and hypoglycemia
• Dermatologic reactions
• Edema
• Weight gain
• Hepatic effects

Pregnancy & Lactation

• Pregnancy category C
• Not recommended during pregnancy or lactation

Precautions & Warnings

• Not for type 1 diabetes or treatment of diabetic ketoacidosis
• Risk of severe hypoglycemia
• Temporary loss of glycemic control under stress
• Caution in patients with edema or heart failure
• Dose-related weight gain
• Hepatic effects and monitoring

Use in Special Populations

• Safety and effectiveness not established in pediatric patients
• No dosage adjustments required for the elderly

Overdose Effects

• Severe hypoglycemia symptoms
• Management with glucagon or IV glucose

Therapeutic Class

• Oral hypoglycemic preparations

Storage Conditions

• Cool and dry place
• Protect from light and moisture
• Keep out of the reach of children

Related Brands

• Dieta Plus 30 mg+4 mg (Tablet) - pacific-pharmaceuticals-ltd