Dieta Plus 30 mg+4 mg (Tablet)

Indications

• Adjunct to diet and exercise
• Improves glycemic control
• Type 2 diabetes therapy
• Combination therapy

Pharmacology

• Insulin-sensitizing agent
• Enhances peripheral glucose utilization
• Decreases insulin resistance
• PPAR-gamma agonist
• Stimulates insulin release
• Increases peripheral tissue sensitivity to insulin

Dosage & Administration

• Once-daily dosing
• Based on current regimen
• Individualized starting doses
• Careful monitoring during dose adjustment

Interactions

• Drugs causing hyperglycemia
• Drugs causing hypoglycemia
• Cytochrome P450 2C9 metabolism interactions

Contraindications

• Hypersensitivity
• Diabetic ketoacidosis

Side Effects

• Upper respiratory tract infection
• Headache
• Myalgia
• Hypoglycemia
• Dizziness
• Edema
• Allergic skin reactions

Pregnancy & Lactation

• Pregnancy category C
• Not recommended for use during pregnancy
• Unknown excretion in human milk

Precautions & Warnings

• Not for type 1 diabetes
• Risk of hypoglycemia
• Loss of glycemic control under stress
• Caution in patients with edema or heart failure risk
• Dose-related weight gain
• Hepatic effects
• Elderly patient susceptibility

Use in Special Populations

• Pediatric safety and effectiveness not established
• Elderly patient pharmacokinetics and renal function considerations

Overdose Effects

• Severe hypoglycemia symptoms
• Management with glucagon or IV glucose

Therapeutic Class

• Combination oral hypoglycemic preparations

Storage Conditions

• Cool and dry storage
• Protection from light and moisture
• Keep out of the reach of children

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