Metglip 2.5 mg+250 mg (Tablet)
Unit Price: ৳ 2.50 (5 x 10: ৳ 125.00)
Strip Price: ৳ 25.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Glipizide metformin hydrochloride |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Indications
- Initial therapy for type 2 diabetes
- Adjunct to diet and exercise
- Improvement of glycemic control
- Second-line therapy for inadequate glycemic control
Pharmacology
- Biguanide antihyperglycemic agent
- Improves glucose tolerance
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Given once or twice daily with meals
- Initiated at a low dose
- Gradual dose escalation
- Recommended starting doses for initial therapy and second-line therapy
- Maximum recommended daily dose
Interaction
- Cimetidine reduces renal clearance of Metformin
- Alcohol potentiates antihyperglycemic effect
- Enhances absorption of Metformin
- Potentiation of hypoglycemic action of sulfonylureas by certain drugs
Contraindications
- Hypersensitivity to the drug
- Renal impairment
- Diabetic coma and ketoacidosis
- Chronic renal diseases
- Congestive heart failure
- Trauma
- Dehydration
- Alcohol dependence
- Pregnancy
- Breast-feeding
Side Effects
- Hypoglycemia
- Diarrhea
- Nausea/vomiting
- Abdominal pain
- Headache
- Musculoskeletal pain
Pregnancy & Lactation
- Contraindicated during Pregnancy & Lactation
Precautions & Warnings
- Substantial excretion by the kidney
- Risk of Metformin accumulation and lactic acidosis
- Careful titration in advanced age
- Temporary suspension for surgical procedures
- Blood glucose monitoring during concomitant therapy with sulfonylurea
- Metabolism and excretion may be slowed in patients with impaired renal and/or hepatic function
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Store below 25°C in a cool and dry place