Compimet 15 mg+500 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pioglitazone metformin hydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Improvement of glycemic control in type 2 diabetes patients
Pharmacology
- Pioglitazone decreases insulin resistance
- Metformin improves glucose tolerance and insulin sensitivity
Dosage & Administration
- Individualized dosing based on effectiveness and tolerability
- Maximum recommended daily dose of Pioglitazone 45 mg and Metformin 2550 mg
- Dosing should be conservative in elderly and renal impaired patients
Interaction
- Impaired vit B12 absorption
- Increased plasma levels with strong CYP2C8 inhibitors
- Decreased plasma levels with CYP2C8 inducers
- Reduced metabolism with cationic drugs eliminated by renal tubular secretion
Contraindications
- Renal disease or dysfunction
- Known hypersensitivity to Pioglitazone or Metformin
- Acute or chronic metabolic acidosis
Side Effects
- Upper respiratory tract infection
- Diarrhea
- Peripheral edema
- Headache
Pregnancy & Lactation
- Use in pregnancy only if potential benefit justifies potential risk to fetus
- Avoid use in breastfeeding women
Precautions & Warnings
- Not for use in type 1 diabetes or diabetic ketoacidosis
- Exercise caution in combination with insulin, hepatic insufficiency, and heart diseases
- Metformin dosage adjustment for impaired renal function
Use in Special Populations
- Careful dosing in elderly and renal impaired patients
Overdose Effects
- Appropriate supportive treatment based on clinical signs and symptoms
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Store in a cool and dry place
- Protect from light and moisture
- Keep out of the reach of children