Piomin 15 mg+850 mg (Tablet)

Unit Price: ৳ 11.50 (3 x 10: ৳ 345.00)

Strip Price: ৳ 115.00

Medicine Details

Category	Details
Generic	Pioglitazone metformin hydrochloride
Company	Pacific pharmaceuticals ltd
Also available as	Piomin 15 mg tablet

Indications

Adjunct to diet and exercise
Improves glycemic control in type 2 diabetes patients

Pharmacology

Pioglitazone mechanism of action
Metformin mechanism of action
Insulin resistance reduction
Glucose disposal enhancement
Lipid metabolism modulation
Glucose absorption decrease
Insulin sensitivity improvement

Dosage & Administration

Individualized antihyperglycemic therapy
Maximum daily dose not to exceed
Divided daily doses with meals
Starting dose for inadequately controlled patients
Titration based on therapeutic response
Maximum recommended dose
Conservative dosing in elderly patients
Monitoring of renal function necessary
Liver enzyme monitoring recommended

Interaction

Impaired vit B12 absorption
Increased plasma levels with CYP2C8 inhibitors
Decreased plasma levels with CYP2C8 inducers
Reduced metabolism with cationic drugs

Contraindications

Renal disease or dysfunction
Hypersensitivity to components
Acute or chronic metabolic acidosis

Side Effects

Upper respiratory tract infection
Diarrhea
Peripheral edema
Headache

Pregnancy & Lactation

Use only if benefit justifies risk to fetus
Not recommended for breastfeeding women

Precautions & Warnings

Not for type 1 diabetes treatment
Caution in combination with insulin
Caution in hepatic insufficiency
Risk of Metformin accumulation in renal impairment

Use in Special Populations

Careful dose selection in advanced age patients
Monitoring of renal function necessary
Not for patients with active liver disease

Overdose Effects

Appropriate supportive treatment required

Therapeutic Class

Oral hypoglycemic preparations

Storage Conditions

Cool and dry storage
Protection from light and moisture
Keep out of the reach of children

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