Piozena Plus 15 mg+500 mg (Tablet)

Unit Price: ৳ 10.00 (2 x 10: ৳ 200.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Pioglitazone metformin hydrochloride
Company Drug international ltd
Also available as
Piozena plus 15 mg tablet

Indications

  • Adjunct to diet and exercise for type 2 diabetes
  • Improves glycemic control
  • Combination therapy with pioglitazone and metformin

Pharmacology

  • Pioglitazone mechanism of action dependent on insulin
  • Decreases insulin resistance
  • Metformin improves glucose tolerance
  • Lowers basal and postprandial plasma glucose

Dosage & Administration

  • Individualized antihyperglycemic therapy
  • Maximum daily dose of pioglitazone 45 mg and metformin 2550 mg
  • Daily divided doses with meals
  • Starting dose based on patient's current regimen
  • Conservative dosing in advanced age
  • Renal function monitoring
  • Liver enzyme monitoring
  • Maximum recommended dose

Interaction

  • May impair vit B12 absorption
  • Increased plasma levels with CYP2C8 inhibitors
  • Decreased plasma levels with CYP2C8 inducers
  • Reduced metabolism with cationic drugs eliminated by renal tubular secretion

Contraindications

  • Renal disease or dysfunction
  • Known hypersensitivity to pioglitazone or metformin
  • Acute or chronic metabolic acidosis

Side Effects

  • Upper respiratory tract infection
  • Diarrhea
  • Peripheral edema
  • Headache

Pregnancy & Lactation

  • Limited studies in pregnant women
  • Potential risk to the fetus
  • Should not be administered to breastfeeding women

Precautions & Warnings

  • Not for use in type 1 diabetes or diabetic ketoacidosis
  • Use with caution in combination with insulin, hepatic insufficiency, and heart diseases
  • Substantial excretion by the kidney
  • Risk of Metformin accumulation and lactic acidosis

Use in Special Populations

  • Careful dosing in advanced age
  • Monitoring of renal function
  • Not for patients with clinical evidence of active liver disease

Overdose Effects

  • Appropriate supportive treatment based on clinical signs and symptoms

Therapeutic Class

  • Combination oral hypoglycemic preparations

Storage Conditions

  • Store in cool and dry place
  • Protect from light and moisture
  • Keep out of reach of children

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