Piozena Plus 15 mg+850 mg (Tablet)
Unit Price: ৳ 11.00 (2 x 10: ৳ 220.00)
Strip Price: ৳ 110.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Pioglitazone metformin hydrochloride |
| Company | Drug international ltd |
| Also available as |
Indications
- Adjunct to diet
- Improves glycemic control
- Type 2 diabetes
- Insufficiently controlled with Metformin
- Responsive to Pioglitazone
- Additional glycemic control
Pharmacology
- Pioglitazone mechanism of action
- Insulin resistance reduction
- Increased insulin-dependent glucose disposal
- Decreased hepatic glucose output
- Highly selective agonist for PPARg
- Modulates transcription of insulin responsive genes
- Metformin mechanism of action
- Improves glucose tolerance
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Increases peripheral glucose uptake
- Improves insulin sensitivity
Dosage & Administration
- Individualized antihyperglycemic therapy
- Maximum recommended daily dose
- Starting dose based on current regimen
- Divided daily doses with meals
- Titration based on therapeutic response
- Maximum recommended dose for Pioglitazone
- Maximum recommended daily dose for Metformin
- Conservative dosing in advanced age
- Monitoring of renal function necessary
- Liver enzyme monitoring recommended
Interaction
- Impaired vit B12 absorption
- Increased plasma levels with CYP2C8 inhibitors
- Decreased plasma levels with CYP2C8 inducers
- Reduced metabolism with cationic drugs
Contraindications
- Renal disease or dysfunction
- Hypersensitivity to Pioglitazone or Metformin
- Acute or chronic metabolic acidosis
Side Effects
- Upper respiratory tract infection
- Diarrhea
- Peripheral edema
- Headache
- Mild severity
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Potential risk to the fetus
- Should not be administered to a breastfeeding woman
Precautions & Warnings
- Not for type 1 diabetes or diabetic ketoacidosis
- Caution in combination with insulin, hepatic insufficiency, and heart diseases
- Risk of Metformin accumulation and lactic acidosis with impaired renal function
Use in Special Populations
- Careful dose selection in advanced age
- Monitoring of renal function
- Liver enzyme monitoring
- Not for patients with active liver disease
Overdose Effects
- Appropriate supportive treatment based on clinical signs and symptoms
Therapeutic Class
- Oral hypoglycemic preparations
Storage Conditions
- Cool and dry place
- Protect from light and moisture
- Keep out of the reach of children