Polimet 15 mg+500 mg (Tablet)
Unit Price: ৳ 8.00 (100's pack: ৳ 800.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Pioglitazone metformin hydrochloride |
| Company | Rephco pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for glycemic control in type 2 diabetes
- Improves insulin sensitivity and glucose disposal
Pharmacology
- Decreases insulin resistance
- Modulates transcription of insulin responsive genes
- Improves glucose tolerance
- Lowers basal and postprandial plasma glucose
Dosage and Administration
- Individualized antihyperglycemic therapy
- Initial and maintenance dosing should be conservative in elderly patients
Interaction
- May impair vit B12 absorption
- Increased plasma levels with strong CYP2C8 inhibitors
- Decreased plasma levels with CYP2C8 inducers
Contraindications
- Renal disease or dysfunction
- Known hypersensitivity to components
- Acute or chronic metabolic acidosis
Side Effects
- Upper respiratory tract infection
- Diarrhea
- Peripheral edema
- Headache
Pregnancy and Lactation
- Potential benefit justifies potential risk to fetus
- Should not be administered to breastfeeding women
Precautions and Warnings
- Should not be used in type 1 diabetes or diabetic ketoacidosis
- Used with caution in combination with insulin, hepatic insufficiency, and heart diseases
Use in Special Populations
- Carefully selected dose for advanced age patients
- Monitoring of renal function necessary
- Liver enzyme monitoring recommended
Overdose Effects
- Appropriate supportive treatment based on clinical signs and symptoms
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Store in a cool and dry place
- Protect from light and moisture
- Keep out of the reach of children