Polimet 15 mg+850 mg (Tablet)

Indications

• Improving glycemic control in patients with type 2 diabetes
• Adjunct to diet and exercise
• Combination therapy for diabetes management
• Patients not adequately controlled with Metformin alone
• Additional glycemic control in patients who initially responded to Pioglitazone
• Improving insulin sensitivity
• Modulating transcription of insulin responsive genes

Pharmacology

• Pioglitazone mechanism of action dependent on insulin presence
• Decreases insulin resistance in periphery and liver
• Increased insulin-dependent glucose disposal
• Selective agonist for peroxisome proliferator-activated receptor-gamma (PPARg)
• Metformin improves glucose tolerance in type 2 diabetes patients
• Decreases hepatic glucose production
• Increases peripheral glucose uptake and utilization
• Does not produce hypoglycemia or hyperinsulinemia

Dosage & Administration

• Individualized antihyperglycemic therapy
• Maximum recommended daily dose of Pioglitazone 45 mg and Metformin 2550 mg
• Divided daily doses with meals
• Starting dose based on patient's current regimen
• Conservative dosing for patients with advanced age
• Monitoring renal function in elderly patients
• Liver enzyme monitoring prior to therapy initiation

Interaction

• May impair vit B12 absorption
• Increased plasma levels with strong CYP2C8 inhibitors
• Decreased plasma levels with CYP2C8 inducers
• Reduced metabolism with cationic drugs

Contraindications

• Renal disease or dysfunction
• Known hypersensitivity to Pioglitazone or Metformin
• Acute or chronic metabolic acidosis

Side Effects

• Upper respiratory tract infection
• Diarrhea
• Peripheral edema
• Headache
• Mild in severity

Pregnancy & Lactation

• Limited studies in pregnant women
• Only used if benefit justifies potential risk to the fetus
• Not recommended for breastfeeding women

Precautions & Warnings

• Not for type 1 diabetes or diabetic ketoacidosis treatment
• Caution in combination with insulin, hepatic insufficiency, and heart diseases
• Risk of Metformin accumulation and lactic acidosis with renal impairment

Use in Special Populations

• Careful dose selection in advanced age patients
• Renal function monitoring in elderly
• Liver enzyme monitoring before therapy initiation

Overdose Effects

• Appropriate supportive treatment according to clinical signs and symptoms

Therapeutic Class

• Oral hypoglycemic preparations

Storage Conditions

• Cool and dry place
• Protect from light and moisture
• Keep out of reach of children

Related Brands

• Compimet 15 mg+850 mg (Tablet) - incepta-pharmaceuticals-ltd