Glipita-M 50 mg+500 mg (Tablet)

Unit Price: ৳ 16.00 (3 x 10: ৳ 480.00)
Strip Price: ৳ 160.00

Medicine Details

Category Details
Generic Sitagliptin metformin hydrochloride
Company Beximco pharmaceuticals ltd
Also available as
Glipita m 50 mg tablet Glipita m xr 50 mg tablet Glipita m xr 50 mg tablet

Indications

  • Adjunct to diet and exercise for type 2 diabetes mellitus
  • Improves glycemic control
  • Adult use only
  • Not indicated for type 1 diabetes or diabetic ketoacidosis

Pharmacology

  • Combines sitagliptin and metformin
  • Antihyperglycemic agents with complementary mechanisms
  • Slows inactivation of incretin hormones
  • Increases insulin release
  • Decreases glucagon levels

Dosage & Administration

  • Individualized dosage
  • Max daily dose of 100mg sitagliptin and 2000mg metformin
  • Given twice daily with meals
  • Gradual dose escalation to reduce GI side effects
  • Different starting doses for new patients and those already taking metformin

Interaction

  • Cationic drugs caution
  • Interaction with phenprocoumon and levothyroxine

Contraindications

  • Contraindicated in renal disease or dysfunction
  • Contraindicated in acute or chronic metabolic acidosis
  • Contraindicated in history of serious hypersensitivity reaction

Side Effects

  • Common adverse reactions like diarrhea, upper respiratory tract infection, headache
  • Hypoglycemia with combination therapy
  • Nasopharyngitis reported with sitagliptin monotherapy
  • Common adverse reactions of metformin like diarrhea, nausea, headache

Pregnancy & Lactation

  • Pregnancy category B
  • Use during pregnancy only if clearly needed
  • Use with caution during lactation

Precautions & Warnings

  • Risk of lactic acidosis
  • Regular monitoring of TSH levels
  • Association with decrease in vitamin B12 levels
  • Precautions for hepatic disease, renal function, and pancreatitis
  • Monitoring of hematologic parameters
  • Warning against excessive alcohol intake

Overdose Effects

  • Supportive measures for sitagliptin overdose
  • Hemodialysis for metformin hydrochloride overdose

Therapeutic Class

  • Combination oral hypoglycemic preparations

Storage Conditions

  • Store below 25°C
  • Keep away from light
  • Keep out of the reach of children
  • Dispensed only on prescription

Related Brands