Glipita-M 50 mg+500 mg (Tablet)

Indications

• Adjunct to diet and exercise for type 2 diabetes mellitus
• Improves glycemic control
• Adult use only
• Not indicated for type 1 diabetes or diabetic ketoacidosis

Pharmacology

• Combines sitagliptin and metformin
• Antihyperglycemic agents with complementary mechanisms
• Slows inactivation of incretin hormones
• Increases insulin release
• Decreases glucagon levels

Dosage & Administration

• Individualized dosage
• Max daily dose of 100mg sitagliptin and 2000mg metformin
• Given twice daily with meals
• Gradual dose escalation to reduce GI side effects
• Different starting doses for new patients and those already taking metformin

Interaction

• Cationic drugs caution
• Interaction with phenprocoumon and levothyroxine

Contraindications

• Contraindicated in renal disease or dysfunction
• Contraindicated in acute or chronic metabolic acidosis
• Contraindicated in history of serious hypersensitivity reaction

Side Effects

• Common adverse reactions like diarrhea, upper respiratory tract infection, headache
• Hypoglycemia with combination therapy
• Nasopharyngitis reported with sitagliptin monotherapy
• Common adverse reactions of metformin like diarrhea, nausea, headache

Pregnancy & Lactation

• Pregnancy category B
• Use during pregnancy only if clearly needed
• Use with caution during lactation

Precautions & Warnings

• Risk of lactic acidosis
• Regular monitoring of TSH levels
• Association with decrease in vitamin B12 levels
• Precautions for hepatic disease, renal function, and pancreatitis
• Monitoring of hematologic parameters
• Warning against excessive alcohol intake

Overdose Effects

• Supportive measures for sitagliptin overdose
• Hemodialysis for metformin hydrochloride overdose

Therapeutic Class

• Combination oral hypoglycemic preparations

Storage Conditions

• Store below 25°C
• Keep away from light
• Keep out of the reach of children
• Dispensed only on prescription

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