Janmet 50 mg+500 mg (Tablet)

Unit Price: ৳ 18.00 (3 x 10: ৳ 540.00)
Strip Price: ৳ 180.00

Medicine Details

Category Details
Generic Sitagliptin metformin hydrochloride
Company Acme laboratories ltd
Also available as
Janmet 50 mg tablet Janmet xr 50 mg tablet

Indications

  • Adjunct to diet and exercise for glycemic control in adults with type 2 diabetes mellitus
  • Not for type 1 diabetes or treatment of diabetic ketoacidosis
  • Not studied in patients with a history of pancreatitis

Pharmacology

  • Combines sitagliptin and metformin for improved glycemic control
  • Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor
  • Metformin HCl belongs to the biguanide class

Dosage & Administration

  • Dosage should be individualized based on current regimen and tolerability
  • Maximum recommended daily dose of 100 mg sitagliptin and 2000 mg metformin
  • Should generally be given twice daily with meals for reduced gastrointestinal side effects

Interaction

  • Use with caution with cationic drugs eliminated by renal tubular secretion
  • Metformin may decrease the anticoagulant effect of phenprocoumon
  • Levothyroxine can reduce the hypoglycemic effect of metformin

Contraindications

  • Renal disease or dysfunction
  • Acute or chronic metabolic acidosis
  • History of serious hypersensitivity reaction to the product

Side Effects

  • Common adverse reactions include diarrhea, upper respiratory tract infection, and headache

Pregnancy & Lactation

  • Pregnancy Category B
  • Should be used during pregnancy only if clearly needed
  • Caution advised when administered to a nursing woman

Precautions & Warnings

  • Lactic acidosis risk increases with certain conditions
  • Regular monitoring of thyroid-stimulating hormone (TSH) levels recommended
  • Long-term treatment may be associated with decreased vitamin B12 levels

Overdose Effects

  • Employ usual supportive measures in case of overdose
  • Sitagliptin is modestly dialyzable
  • Metformin is dialyzable with clearance of up to 170 mL/min

Therapeutic Class

  • Combination oral hypoglycemic preparations

Storage Conditions

  • Store below 25°C in a dry place away from light
  • Keep out of the reach of children
  • Dispense only on the prescription of a registered physician

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