Janmet 50 mg+500 mg (Tablet)
Unit Price: ৳ 18.00 (3 x 10: ৳ 540.00)
Strip Price: ৳ 180.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sitagliptin metformin hydrochloride |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for glycemic control in adults with type 2 diabetes mellitus
- Not for type 1 diabetes or treatment of diabetic ketoacidosis
- Not studied in patients with a history of pancreatitis
Pharmacology
- Combines sitagliptin and metformin for improved glycemic control
- Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor
- Metformin HCl belongs to the biguanide class
Dosage & Administration
- Dosage should be individualized based on current regimen and tolerability
- Maximum recommended daily dose of 100 mg sitagliptin and 2000 mg metformin
- Should generally be given twice daily with meals for reduced gastrointestinal side effects
Interaction
- Use with caution with cationic drugs eliminated by renal tubular secretion
- Metformin may decrease the anticoagulant effect of phenprocoumon
- Levothyroxine can reduce the hypoglycemic effect of metformin
Contraindications
- Renal disease or dysfunction
- Acute or chronic metabolic acidosis
- History of serious hypersensitivity reaction to the product
Side Effects
- Common adverse reactions include diarrhea, upper respiratory tract infection, and headache
Pregnancy & Lactation
- Pregnancy Category B
- Should be used during pregnancy only if clearly needed
- Caution advised when administered to a nursing woman
Precautions & Warnings
- Lactic acidosis risk increases with certain conditions
- Regular monitoring of thyroid-stimulating hormone (TSH) levels recommended
- Long-term treatment may be associated with decreased vitamin B12 levels
Overdose Effects
- Employ usual supportive measures in case of overdose
- Sitagliptin is modestly dialyzable
- Metformin is dialyzable with clearance of up to 170 mL/min
Therapeutic Class
- Combination oral hypoglycemic preparations
Storage Conditions
- Store below 25°C in a dry place away from light
- Keep out of the reach of children
- Dispense only on the prescription of a registered physician