Sitagil M 50 mg+500 mg (Tablet (Extended Release))
Unit Price: ৳ 16.00 (5 x 4: ৳ 320.00)
Strip Price: ৳ 64.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sitagliptin metformin hydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for type 2 diabetes mellitus
- Improves glycemic control
- Limitations of use for type 1 diabetes and diabetic ketoacidosis
- Not studied in patients with a history of pancreatitis
Pharmacology
- Combines sitagliptin and metformin
- Dipeptidyl peptidase-4 (DPP-4) inhibitor
- Biguanide class agent
- Mechanisms of action for glycemic control
- Incretin hormones regulation
- Effects on insulin synthesis and release
- Decreases hepatic glucose production
- Increases peripheral glucose uptake and utilization
Dosage & Administration
- Individualized dosage
- Maximum recommended daily dose
- Twice daily administration with meals
- Gradual dose escalation
- Starting dose based on current regimen
- Recommended starting dose for different patient scenarios
- Extended-release tablet administration
- Dosing adjustments with insulin or insulin secretagogue co-administration
Interaction
- Cationic drugs caution
- Interaction with phenprocoumon
- Levothyroxine interaction
- Monitoring and dosage adjustments for interactions
Contraindications
- Renal disease or dysfunction
- Metabolic acidosis
- History of hypersensitivity reactions
- Temporary discontinuation for radiologic studies
Side Effects
- Common adverse reactions
- Adverse reactions with specific combinations
- Adverse reactions due to metformin therapy initiation
Pregnancy & Lactation
- Pregnancy Category B
- Limited studies in pregnant women
- Caution during breastfeeding
Precautions & Warnings
- Risk of lactic acidosis
- Symptoms and monitoring for acidosis
- Monitoring of thyroid-stimulating hormone levels
- Vitamin B12 level monitoring
- Hepatic disease precautions
- Renal function assessment
- Acute pancreatitis risk
- Hematologic parameter monitoring
- Caution against excessive alcohol intake
- Temporary insulin use during stress
- Monitoring for ketoacidosis or lactic acidosis
- Hypersensitivity reactions warning
- No conclusive evidence of macrovascular risk reduction
Overdose Effects
- Supportive measures for sitagliptin overdose
- Dialyzability of sitagliptin
- Overdose and dialyzability of metformin
- Pancreatitis risk with metformin overdose
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Storage temperature
- Dry place away from light
- Safe storage away from children
- Expiry date
- Prescription requirement