Incrit-M 50 mg+500 mg (Tablet)
Unit Price: ৳ 20.06 (2 x 10: ৳ 401.20)
Strip Price: ৳ 200.60
Medicine Details
Category | Details |
---|---|
Generic | Sitagliptin metformin hydrochloride |
Company | Synovia pharma plc |
Also available as |
Indications
- Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
- Appropriate for patients with both sitagliptin and metformin treatment
- Limitations of use in patients with type 1 diabetes
- Limitations of use for the treatment of diabetic ketoacidosis
- Not studied in patients with a history of pancreatitis
Pharmacology
- Combination of sitagliptin and metformin
- Dipeptidyl peptidase-4 (DPP-4) inhibitor
- Mechanism of action of sitagliptin
- Mechanism of action of metformin
- Actions on glucose homeostasis
Dosage & Administration
- Individualized dosage based on patient's current regimen
- Maximum recommended daily dose
- Dose escalation to reduce gastrointestinal side effects
- Recommended starting dose for patients not currently treated with metformin
- Recommended starting dose for patients already treated with metformin
- Dose of extended-release tablet
Interaction
- Cationic drugs and renal tubular secretion
- Interaction with phenprocoumon
- Interaction with levothyroxine
Contraindications
- Renal disease or dysfunction
- Acute or chronic metabolic acidosis
- History of serious hypersensitivity reaction
- Radiologic studies involving intravascular administration of iodinated contrast materials
Side Effects
- Common adverse reactions reported in patients started on sitagliptin and metformin
- Adverse reactions reported in patients treated with sitagliptin in combination with sulfonylurea and metformin
- Adverse reactions reported in patients treated with sitagliptin in combination with insulin and metformin
- Adverse reactions due to initiation of metformin therapy
Pregnancy & Lactation
- Pregnancy Category B
- Caution when administered to a nursing woman
Precautions & Warnings
- Lactic Acidosis
- Monitoring of thyroid-stimulating hormone (TSH) levels
- Association with decrease in vitamin B12 serum levels
- Postmarketing reports of acute renal failure
- Postmarketing reports of acute pancreatitis
- Hematologic parameter monitoring
- Discontinuation and temporary use of insulin during periods of stress
- Evaluation for evidence of ketoacidosis or lactic acidosis
- Allergic and hypersensitivity reactions
Overdose Effects
- Overdose measures for sitagliptin
- Overdose measures for metformin hydrochloride
Therapeutic Class
- Oral hypoglycemic preparations
Storage Conditions
- Store below 25°C in a dry place away from light
- Keep the medicines in a safe place, out of the reach of children
- Do not use later than the date of expiry
- To be dispensed only on the prescription of a registered physician
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