Incrit-M 50 mg+1000 mg (Tablet)

Unit Price: ৳ 22.07 (3 x 6: ৳ 397.26)
Strip Price: ৳ 132.42

Medicine Details

Category Details
Generic Sitagliptin metformin hydrochloride
Company Synovia pharma plc
Also available as
Incrit m 50 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control
  • Type 2 diabetes mellitus
  • Not for type 1 diabetes
  • Limitations of use
  • History of pancreatitis
  • Renal disease contraindication
  • Diabetic ketoacidosis contraindication
  • Hypersensitivity reaction contraindication
  • Contraindicated in radiologic studies
  • Glycemic control mechanism of action
  • Incretin hormones
  • Glucagon-like peptide-1 (GLP-1)
  • Gastrointestinal side effects reduction
  • Maximum recommended daily dose
  • Insulin levels modulation

Pharmacology

  • Combines two antihyperglycemic agents
  • Complementary mechanisms of action
  • Sitagliptin - DPP-4 inhibitor
  • Metformin HCl - biguanide class
  • Slows incretin hormone inactivation
  • GLP-1 and GIP signaling pathways
  • Hepatic glucose production decrease
  • Intestinal glucose absorption decrease
  • Peripheral glucose uptake increase
  • Incretin levels increase

Dosage & Administration

  • Individualized dosage
  • Twice daily with meals
  • Dosage escalation for tolerance
  • Starting dose based on regimen
  • Extended-release tablet administration
  • Insulin or insulin secretagogue co-administration
  • Dosing adjustment for changing tablets
  • Lower doses for co-administration

Interaction

  • Renal tubular secretion caution
  • Anticoagulant effect alteration
  • Levothyroxine hypoglycemic effect reduction

Contraindications

  • Renal dysfunction
  • Metabolic acidosis
  • Hypersensitivity reaction history
  • Radiologic study contraindication

Side Effects

  • Diarrhea
  • Upper respiratory tract infection
  • Headache
  • Hypoglycemia
  • Nasopharyngitis
  • Nausea/vomiting
  • Fatulence
  • Abdominal discomfort
  • Indigestion
  • Asthenia

Pregnancy & Lactation

  • Pregnancy Category B
  • No adequate studies in pregnant women
  • Caution during lactation

Precautions & Warnings

  • Lactic acidosis risk factors
  • Thyroid-stimulating hormone monitoring
  • Vitamin B12 level monitoring
  • Hepatic disease caution
  • Renal function assessment
  • Pancreatitis suspicion
  • Hematologic parameters monitoring
  • Alcohol intake warning
  • Insulin use during stress periods
  • Hypersensitivity reaction risk
  • Ketoacidosis monitoring
  • Macrovascular risk reduction
  • Alternative diabetes treatment initiation

Overdose Effects

  • Supportive measures
  • Dialyzable components
  • Hemodialysis consideration
  • Pancreatitis risk

Therapeutic Class

  • Oral hypoglycemic preparations

Storage Conditions

  • Below 25°C storage
  • Protection from light
  • Expiry date adherence
  • Dispensation only with prescription

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