Siglimet XR 100 mg+1000 mg (Tablet (Extended Release))

Unit Price: ৳ 30.00 (2 x 6: ৳ 360.00)
Strip Price: ৳ 180.00

Medicine Details

Category Details
Generic Sitagliptin metformin hydrochloride
Company Square pharmaceuticals plc
Also available as
Siglimet 50 mg tablet Siglimet 50 mg tablet Siglimet xr 50 mg tablet Siglimet xr 50 mg tablet

Title

  • Combination Oral Hypoglycemic Tablet

Categories

  • Medicine
  • Diabetes Management

Description

  • Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
  • Combines two antihyperglycemic agents with complementary mechanisms of action
  • Dosage to be individualized based on patient's current regimen and tolerability
  • Common adverse reactions include diarrhea, upper respiratory tract infection, and headache
  • Pregnancy Category B
  • Storage below 25°C in a dry place away from light

Color Options

  • White

Size

  • Film-coated tablet
  • Extended-release tablet

Function

  • Improve glycemic control
  • Decrease hepatic glucose production
  • Increase insulin release

Dosage & Administration

  • Film-coated tablet:
    • Initial dose based on patient's current regimen
    • Given twice daily with meals
    • Gradual dose escalation to reduce gastrointestinal side effects
  • Extended-release tablet:
    • Administer once daily with a meal
    • Gradually escalate the dose to reduce GI side effects

Ingredients

  • Sitagliptin
  • Metformin HCl

Pharmacologic Mechanism

  • Sitagliptin: Dipeptidyl peptidase-4 (DPP-4) inhibitor
  • Metformin HCl: Decreases hepatic glucose production, decreases intestinal absorption of glucose, increases peripheral glucose uptake

Usability Features

  • Individualized therapy based on patient's condition
  • Caution in patients with renal dysfunction
  • Regular monitoring of thyroid-stimulating hormone (TSH) levels

Drug Interaction

  • Cationic Drugs: Use with caution in drugs eliminated by renal tubular secretion
  • Phenprocoumon: Metformin may decrease anticoagulant effect
  • Levothyroxine: Can reduce the hypoglycemic effect of metformin

Contraindications

  • Renal disease or dysfunction
  • Acute or chronic metabolic acidosis
  • Serious hypersensitivity reaction to the tablet or sitagliptin

Side Effects

  • Diarrhea
  • Upper respiratory tract infection
  • Headache
  • Hypoglycemia
  • Nasopharyngitis
  • Nausea/vomiting
  • Abdominal discomfort

Pregnancy & Lactation

  • Pregnancy Category B
  • Use during pregnancy only if clearly needed
  • Caution in nursing women

Precautions & Warnings

  • Lactic Acidosis risk factors and symptoms
  • Avoid in patients with hepatic disease
  • Assessment of renal function
  • Potential risk of pancreatitis
  • Monitoring of vitamin B12 levels
  • Postmarketing reports of serious allergic and hypersensitivity reactions

Overdose Effects

  • Sitagliptin: Employ usual supportive measures, consider hemodialysis
  • Metformin hydrochloride: Dialyzable, hemodialysis may be useful

Therapeutic Class

  • Oral hypoglycemic preparations

Storage Conditions

  • Below 25°C in a dry place away from light

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