Sitalia M 50 mg+500 mg (Tablet)

Unit Price: ৳ 12.00 (2 x 10: ৳ 240.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Sitagliptin metformin hydrochloride
Company Delta pharma ltd
Also available as
Sitalia m xr 50 mg tablet

Indications

  • Adjunct to diet and exercise for glycemic control in adults with type 2 diabetes mellitus
  • Not indicated for type 1 diabetes or diabetic ketoacidosis
  • Not studied in patients with a history of pancreatitis

Pharmacology

  • Combines sitagliptin and metformin
  • Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor
  • Metformin HCl belongs to the biguanide class

Dosage & Administration

  • Individualized dosage based on patient's current regimen, effectiveness, and tolerability
  • Maximum recommended daily dose of 100 mg sitagliptin and 2000 mg metformin
  • Gradual dose escalation to reduce gastrointestinal side effects
  • Twice daily administration with meals
  • Starting dose based on patient's current regimen

Interaction

  • Cationic drugs eliminated by renal tubular secretion
  • Metformin may decrease the anticoagulant effect of phenprocoumon
  • Levothyroxine can reduce the hypoglycemic effect of metformin

Contraindications

  • Renal disease or dysfunction
  • Acute or chronic metabolic acidosis
  • History of serious hypersensitivity reaction to the tablet or sitagliptin
  • Use should be temporarily discontinued in patients undergoing radiologic studies with iodinated contrast materials

Side Effects

  • Common adverse reactions include diarrhea, upper respiratory tract infection, and headache
  • Hypoglycemia reported in patients simultaneously started on sitagliptin and metformin
  • Nasopharyngitis reported in patients treated with sitagliptin monotherapy
  • Common adverse reactions due to initiation of metformin therapy include diarrhea, nausea/vomiting, and headache

Pregnancy & Lactation

  • Pregnancy Category B
  • Use during pregnancy only if clearly needed
  • Caution advised when administered to a nursing woman

Precautions & Warnings

  • Lactic acidosis risk increases with certain conditions
  • Monitoring of thyroid-stimulating hormone (TSH) and vitamin B12 levels recommended
  • Do not use in patients with hepatic disease
  • Regular assessment of renal function and hematologic parameters recommended
  • Warn against excessive alcohol intake
  • Need for temporary use of insulin during periods of stress and decreased intake of fluids and food
  • Prompt evaluation for evidence of ketoacidosis or lactic acidosis
  • Consideration of lower dose of insulin secretagogue or insulin when used in combination

Overdose Effects

  • In the event of an overdose, employ usual supportive measures
  • Sitagliptin is modestly dialyzable
  • Metformin is dialyzable with a clearance of up to 170 mL/min

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Store below 25°C in a dry place away from light
  • Keep out of the reach of children
  • Do not use later than the date of expiry
  • Dispense only on the prescription of a registered physician

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