Sitavia-M 50 mg+500 mg (Tablet)
Unit Price: ৳ 16.00 (2 x 10: ৳ 320.00)
Strip Price: ৳ 160.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sitagliptin metformin hydrochloride |
| Company | Sharif pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for glycemic control in adults with type 2 diabetes mellitus
- Not for use in patients with type 1 diabetes or for diabetic ketoacidosis
- Not studied in patients with a history of pancreatitis
Pharmacology
- Combines sitagliptin and metformin for glycemic control in type 2 diabetes
- Sitagliptin is a DPP-4 inhibitor affecting incretin hormones
- Metformin decreases hepatic glucose production, intestinal glucose absorption, and increases glucose uptake
Dosage & Administration
- Maximum daily dose of 100 mg sitagliptin and 2000 mg metformin
- Initial combination therapy or maintenance should be individualized
- Gradual dose escalation to reduce gastrointestinal side effects
- Recommended starting doses for different patient scenarios
- Extended-release tablet dosage and administration details
Interaction
- Cationic drugs elimination caution
- Potential interactions with phenprocoumon and levothyroxine
Contraindications
- Contraindicated in patients with renal disease or dysfunction
- Contraindicated in acute or chronic metabolic acidosis
- Contraindicated in history of serious hypersensitivity reactions
Side Effects
- Common adverse reactions such as diarrhea, upper respiratory tract infection, and headache
- Hypoglycemia and headache in combination with sulfonylurea and metformin
- Nasopharyngitis in sitagliptin monotherapy
- Common metformin adverse reactions
Pregnancy & Lactation
- Pregnancy Category B, use only if clearly needed
- Caution advised for nursing women
Precautions & Warnings
- Risk of lactic acidosis and associated conditions
- Monitoring recommendations for thyroid-stimulating hormone and vitamin B12 levels
- Precautions for patients with hepatic disease and renal function assessment
- Warnings for acute pancreatitis, allergic reactions, and macrovascular risk
Overdose Effects
- Supportive measures for sitagliptin overdose
- Hemodialysis for metformin overdose and risk of pancreatitis
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Store below 25°C in a dry place away from light
- Keep out of reach of children and dispense only on prescription