Sitomet 50 mg+500 mg (Tablet)
Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sitagliptin metformin hydrochloride |
| Company | Aci limited |
| Also available as |
Therapeutic Class
- Combination Oral hypoglycemic preparations
Indications
- Improving glycemic control in adults with type 2 diabetes mellitus
- Adjunct to diet and exercise
Pharmacology
- Combines two antihyperglycemic agents with complementary mechanisms of action
- Sitagliptin - DPP-4 inhibitor affecting insulin release and glucagon levels
- Metformin HCl - decreases hepatic glucose production, intestinal absorption of glucose, and increases peripheral glucose uptake
Dosage & Administration
- Individualized dosage based on current regimen, effectiveness, and tolerability
- Maximum recommended daily dose of 100 mg sitagliptin and 2000 mg metformin
- Initial combination therapy or maintenance should be individualized
- Twice daily administration with meals
- Gradual dose escalation to reduce gastrointestinal side effects
Interaction
- Cationic drugs elimination caution
- Metformin may decrease the anticoagulant effect of phenprocoumon
- Levothyroxine can reduce the hypoglycemic effect of metformin
Contraindications
- Renal disease or dysfunction
- Acute or chronic metabolic acidosis
- History of serious hypersensitivity reaction to the tablet or sitagliptin
- Undergoing radiologic studies involving intravascular administration of iodinated contrast materials
Side Effects
- Common adverse reactions include diarrhea, upper respiratory tract infection, headache
- Hypoglycemia, nasopharyngitis, and gastrointestinal discomfort reported
Pregnancy & Lactation
- Pregnancy Category B
- Caution during nursing as excretion in human milk is unknown
Precautions & Warnings
- Risk of lactic acidosis with specific conditions
- Regular monitoring of thyroid-stimulating hormone (TSH) levels recommended
- Decrease in vitamin B12 serum levels potential with long-term use
- Avoid use in hepatic disease, assess renal function before initiation
Overdose Effects
- Employ usual supportive measures in event of overdose
- Hemodialysis may be considered for metformin overdose
Storage Conditions
- Store below 25°C in a dry place away from light
- Keep out of the reach of children
- Do not use beyond expiry date