Sitomet 50 mg+500 mg (Tablet)

Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Sitagliptin metformin hydrochloride
Company Aci limited
Also available as
Sitomet 50 mg tablet

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Indications

  • Improving glycemic control in adults with type 2 diabetes mellitus
  • Adjunct to diet and exercise

Pharmacology

  • Combines two antihyperglycemic agents with complementary mechanisms of action
  • Sitagliptin - DPP-4 inhibitor affecting insulin release and glucagon levels
  • Metformin HCl - decreases hepatic glucose production, intestinal absorption of glucose, and increases peripheral glucose uptake

Dosage & Administration

  • Individualized dosage based on current regimen, effectiveness, and tolerability
  • Maximum recommended daily dose of 100 mg sitagliptin and 2000 mg metformin
  • Initial combination therapy or maintenance should be individualized
  • Twice daily administration with meals
  • Gradual dose escalation to reduce gastrointestinal side effects

Interaction

  • Cationic drugs elimination caution
  • Metformin may decrease the anticoagulant effect of phenprocoumon
  • Levothyroxine can reduce the hypoglycemic effect of metformin

Contraindications

  • Renal disease or dysfunction
  • Acute or chronic metabolic acidosis
  • History of serious hypersensitivity reaction to the tablet or sitagliptin
  • Undergoing radiologic studies involving intravascular administration of iodinated contrast materials

Side Effects

  • Common adverse reactions include diarrhea, upper respiratory tract infection, headache
  • Hypoglycemia, nasopharyngitis, and gastrointestinal discomfort reported

Pregnancy & Lactation

  • Pregnancy Category B
  • Caution during nursing as excretion in human milk is unknown

Precautions & Warnings

  • Risk of lactic acidosis with specific conditions
  • Regular monitoring of thyroid-stimulating hormone (TSH) levels recommended
  • Decrease in vitamin B12 serum levels potential with long-term use
  • Avoid use in hepatic disease, assess renal function before initiation

Overdose Effects

  • Employ usual supportive measures in event of overdose
  • Hemodialysis may be considered for metformin overdose

Storage Conditions

  • Store below 25°C in a dry place away from light
  • Keep out of the reach of children
  • Do not use beyond expiry date

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