Sliptin-M ER 50 mg+500 mg (Tablet (Extended Release))

Unit Price: ৳ 16.05 (2 x 7: ৳ 224.70)
Strip Price: ৳ 112.35

Medicine Details

Category Details
Generic Sitagliptin metformin hydrochloride
Company Drug international ltd
Also available as
Sliptin m 50 mg tablet Sliptin m 50 mg tablet Sliptin m er 50 mg tablet

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control
  • Type 2 diabetes mellitus
  • Limitations of use
  • Not for type 1 diabetes
  • Not for treatment of diabetic ketoacidosis
  • Not studied in pancreatitis patients

Pharmacology

  • Combines two antihyperglycemic agents
  • Complementary mechanisms of action
  • Dipeptidyl peptidase-4 (DPP-4) Inhibitor
  • Biguanide class
  • Incretin hormones regulation
  • Physiological regulation of glucose homeostasis
  • GLP-1 and GIP hormone effects
  • Insulin and glucagon regulation
  • Glucose uptake and utilization
  • Hepatic glucose production

Dosage & Administration

  • Individualized dosage
  • Maximum recommended daily dose
  • Twice daily with meals
  • Gradual dose escalation
  • Reducing gastrointestinal side effects
  • Starting dose based on current regimen
  • Extended-release tablet dosing
  • Insulin and insulin secretagogue co-administration

Interaction

  • Cationic drugs caution
  • Phenprocoumon effect
  • Levothyroxine impact on hypoglycemic effect

Contraindications

  • Renal disease or dysfunction
  • Metabolic acidosis
  • History of hypersensitivity reaction
  • Radiologic studies precaution

Side Effects

  • Common adverse reactions
  • Specific reactions for different treatment combinations
  • Metformin therapy adverse reactions

Pregnancy & Lactation

  • Pregnancy Category B
  • Safety during pregnancy
  • Excretion in human milk caution

Precautions & Warnings

  • Lactic Acidosis risk factors and symptoms
  • Thyroid-stimulating hormone monitoring
  • Vitamin B12 level monitoring
  • Hepatic disease caution
  • Renal function assessment
  • Pancreatitis risk
  • Hematologic parameters monitoring
  • Alcohol intake warning
  • Insulin use during stress
  • Allergic and hypersensitivity reactions
  • Macrovascular risk reduction

Overdose Effects

  • Sitagliptin overdose measures
  • Sitagliptin dialyzability
  • Metformin hydrochloride overdose and dialyzability
  • Pancreatitis in metformin overdose

Therapeutic Class

  • Combination oral hypoglycemic preparations

Storage Conditions

  • Temperature and light storage
  • Keep away from children
  • Expiry date importance
  • Dispensing only on prescription

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