Dialiptin-M 50 mg+850 mg (Tablet)

Indications

• adjunct to diet
• improve glycaemic control
• type 2 diabetes mellitus

Pharmacology

• inhibiting DPP-4
• GLP-1 and GIP hormones
• insulin secretion
• glucagon secretion
• decreases hepatic glucose production

Dosage & Administration

• initiated at twice daily
• 1 tablet in the morning and evening
• switching from separate tablets
• doses higher than 100mg not recommended
• reduced gastrointestinal symptoms

Interaction

• no clinically relevant pharmacokinetic interaction
• low potential for drug interactions
• does not interact with CYP 450 enzymes
• no clinically relevant interactions with other oral antidiabetics

Contraindications

• known hypersensitivity to Vildagliptin or Metformin Hydrochloride
• renal disease or dysfunction
• acute myocardial infarction
• septicaemia
• congestive heart failure
• acute or chronic metabolic acidosis

Side Effects

• headache
• tremor
• dizziness
• nausea
• hypoglycemia

Pregnancy & Lactation

• not recommended during pregnancy
• no studies in pregnant women
• not administered to breast-feeding women

Precautions & Warnings

• lactic acidosis
• metabolic acidosis suspected
• renal function monitoring
• liver function tests monitoring
• discontinued before elective surgery
• resume after 48 hours of surgery

Use in Special Populations

• not recommended for use in children below 18 years
• monitor renal function in elderly patients
• elderly patients with normal renal function
• not recommended in patients with renal failure
• not recommended in patients with hepatic impairment

Therapeutic Class

• Combination Oral hypoglycemic preparations

Storage Conditions

• dry place away from light and heat
• keep out of reach of children

Related Brands

• Dialiptin-M 50 mg+500 mg (Tablet) - drug-international-ltd