Gluvan Plus 50 mg+850 mg (Tablet)

Unit Price: ৳ 25.00 (5 x 4: ৳ 500.00)

Strip Price: ৳ 100.00

Medicine Details

Category	Details
Generic	Vildagliptin metformin hydrochloride
Company	Aristopharma ltd
Also available as	Gluvan plus 50 mg tablet

Therapeutic Class

Combination Oral hypoglycemic preparations

Indications

Adjunct to diet and exercises to improve glycaemic control in type 2 diabetes mellitus patients

Pharmacology

Acts by inhibiting DPP-4 enzyme
Increases insulin secretion
Decreases glucagon secretion
Lowers both basal and postprandial plasma glucose
Decreases hepatic glucose production
Improves insulin sensitivity

Dosage & Administration

Initiated at twice daily
Recommended to be taken with or just after food

Interaction

Low potential for drug interactions
No clinically relevant interactions with other oral antidiabetics
Increased Cmax and blood AUC of Metformin with certain medications

Contraindications

Known hypersensitivity to Vildagliptin or Metformin Hydrochloride
Renal disease or dysfunction
Acute myocardial infarction
Septicaemia
Congestive heart failure
Acute or chronic metabolic acidosis
Use during radiologic studies involving intravascular administration of iodinated contrast materials

Side Effects

Headache
Tremor
Dizziness
Nausea
Hypoglycaemia

Pregnancy & Lactation

Not recommended during pregnancy unless potential benefit justifies potential risk to the foetus
Not recommended for breast-feeding women

Precautions & Warnings

Risk of lactic acidosis
Monitoring of serum creatinine and liver function
Special caution in elderly patients
Discontinue in case of jaundice or liver dysfunction
Discontinue 48 hours before elective surgery with general anaesthesia

Use in Special Populations

Not recommended for use in children below 18 years of age
Renal function monitoring in elderly patients
Not recommended in patients with renal or hepatic impairment

Storage Conditions

Keep in a dry place away from light and heat
Keep out of the reach of children

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