Viglimet 50 mg+500 mg (Tablet)

Unit Price: ৳ 20.00 (5 x 6: ৳ 600.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Vildagliptin metformin hydrochloride
Company Square pharmaceuticals plc
Also available as
Viglimet 50 mg tablet

Product Title, Categories, and Description

  • Viglimet Tablet
  • Indications
  • Pharmacology
  • Dosage & Administration
  • Interaction
  • Contraindications
  • Side Effects
  • Pregnancy & Lactation
  • Precautions & Warnings
  • Use in Special Populations
  • Therapeutic Class
  • Storage Conditions

Purpose

  • Adjunct to diet and exercises to improve glycaemic control in patients with type 2 diabetes mellitus

Ingredients

  • Vildagliptin
  • Metformin Hydrochloride

Mechanism of Action

  • Inhibits DPP-4 enzyme
  • Inhibition of DPP-4 activity
  • Increases insulin secretion
  • Decreases glucagon secretion
  • Lowers basal and postprandial plasma glucose
  • Decreases hepatic glucose production
  • Improves insulin sensitivity
  • Increase in peripheral glucose uptake and utilization
  • Decreases intestinal absorption of glucose

Dosage Instructions

  • Twice daily administration
  • May be initiated based on current Metformin dose
  • Doses higher than 100 mg of vildagliptin are not recommended
  • May be taken with or just after food to reduce gastrointestinal symptoms associated with Metformin

Pharmacokinetic Interaction

  • No clinically relevant interaction observed between Vildagliptin and Metformin Hydrochloride
  • Low potential for drug interactions
  • Does not interact with CYP 450 enzymes

Contraindications

  • Known hypersensitivity to Vildagliptin or Metformin Hydrochloride or to any of the excipients
  • Renal disease or dysfunction
  • Acute myocardial infarction
  • Septicaemia
  • Congestive heart failure
  • Acute or chronic metabolic acidosis including diabetic ketoacidosis
  • Use with iodinated contrast materials

Side Effects

  • Headache
  • Tremor
  • Dizziness
  • Nausea
  • Hypoglycemia

Pregnancy & Lactation

  • Not recommended during pregnancy unless potential benefit justifies potential risk to the fetus
  • Not recommended for use in breastfeeding women

Precautions & Warnings

  • Possible occurrence of lactic acidosis due to Metformin accumulation
  • Serum creatinine monitoring
  • Special caution in elderly patients
  • Liver Function Tests monitoring
  • Discontinuation prior to certain medical procedures

Use in Special Populations

  • Not recommended for pediatric patients
  • Renal function monitoring for elderly patients
  • Not recommended in patients with renal or hepatic impairment

Therapeutic Class

  • Oral hypoglycemic preparations

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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