Vildamet 50 mg+500 mg (Tablet)
Unit Price: ৳ 22.06 (2 x 10: ৳ 441.20)
Strip Price: ৳ 220.60
Medicine Details
Category | Details |
---|---|
Generic | Vildagliptin metformin hydrochloride |
Company | Opsonin pharma ltd |
Also available as |
Indications
- Adjunct to diet and exercises for type 2 diabetes mellitus
- Improves glycaemic control
- Used when diabetes is not controlled on Metformin or Vildagliptin alone
Pharmacology
- Inhibits DPP-4 (Dipeptidyl peptidase-4)
- Increases insulin secretion
- Decreases glucagon secretion
- Lowers basal and postprandial plasma glucose
- Improves insulin sensitivity
Dosage & Administration
- Initiated at twice daily
- 1 tablet in the morning and 1 tablet in the evening
- May be switched from separate tablets with same doses of each component
- Taking with or just after food may reduce gastrointestinal symptoms
Interaction
- No clinically relevant pharmacokinetic interaction observed with Metformin Hydrochloride
- Low potential for drug interactions with CYP 450 enzymes
- No clinically relevant interactions with other oral antidiabetics, amlodipine, digoxin, ramipril, simvastatin, valsartan or warfarin
Contraindications
- Known hypersensitivity to Vildagliptin or Metformin Hydrochloride
- Renal disease or dysfunction
- Acute myocardial infarction
- Septicaemia
- Congestive heart failure
- Acute or chronic metabolic acidosis including diabetic ketoacidosis
- Use with iodinated contrast materials
Side Effects
- Headache
- Tremor
- Dizziness
- Nausea
- Hypoglycaemia
Pregnancy & Lactation
- Not recommended during pregnancy unless potential benefit justifies potential risk to the foetus
- Not known whether excreted in human milk
Precautions & Warnings
- Lactic acidosis can occur due to Metformin accumulation
- Serum creatinine should be monitored regularly
- Special caution in elderly patients and those with impaired renal or hepatic function
- Liver Function Tests (LFTs) should be monitored prior to initiation and periodically thereafter
- Discontinue 48 hours before elective surgery with general anaesthesia
Use in Special Populations
- Not recommended for use in children below 18 years of age
- Regular renal function monitoring in elderly patients
- Not recommended in patients with renal or hepatic impairment
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children
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