Viptin Plus 50 mg+500 mg (Tablet)

Indications

• Adjunct to diet and exercises
• Type 2 diabetes mellitus
• Glycaemic control
• Metformin Hydrochloride
• Vildagliptin

Pharmacology

• Inhibition of DPP-4
• GLP-1
• GIP
• Insulin secretion
• Glucagon secretion
• Hepatic glucose production
• Basal and postprandial plasma glucose
• Insulin sensitivity
• Peripheral glucose uptake
• Utilization

Dosage & Administration

• Initiation
• Twice daily
• Morning dose
• Evening dose
• Clinical experience
• Triple combination
• Gastrointestinal symptom reduction

Interaction

• Pharmacokinetic interaction
• Cytochrome P 450 enzyme
• Drug interactions
• Oral antidiabetics
• Amlodipine
• Digoxin
• Ramipril
• Simvastatin
• Valsartan
• Warfarin
• Furosemide
• Nifedipine
• Glyburide
• Renal clearance

Contraindications

• Hypersensitivity
• Renal disease
• Acute myocardial infarction
• Septicaemia
• Congestive heart failure
• Metabolic acidosis
• Coma
• Radiologic studies
• Iodinated contrast materials

Side Effects

• Headache
• Tremor
• Dizziness
• Nausea
• Hypoglycemia

Pregnancy & Lactation

• Pregnancy studies
• Breastfeeding
• Excretion in human milk
• Foetal risk assessment

Precautions & Warnings

• Lactic acidosis
• Metabolic acidosis
• Hospitalization
• Renal function monitoring
• Elderly patients
• Liver Function Tests
• Transaminase levels
• Jaundice
• Liver dysfunction
• Elective surgery
• General anaesthesia

Use in Special Populations

• Pediatric patients
• Geriatric patients
• Renal impairment
• Hepatic impairment

Therapeutic Class

• Oral hypoglycemic preparations

Storage Conditions

• Dry place
• Light and heat protection
• Keep out of the reach of children

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