Thyrin 25 mcg (Tablet)
Unit Price: ৳ 1.11 (6 x 15: ৳ 99.90)
Strip Price: ৳ 16.65
Medicine Details
| Category | Details |
|---|---|
| Generic | Levothyroxine sodium |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Replacement therapy in hypothyroidism of any etiology
- Suppression of Thyroid Stimulating Hormone (TSH) levels
- Suppression of goitrogenic effects of other drugs
- Diagnostic aid in suppression tests
Pharmacology
- Contains synthetic Levothyroxine (Thyroxine or T4)
- T4 converted to Triiodothyronine (T3) in peripheral tissues
- TBG (Thyroxine Binding Globulin) as major carrier of T4
- Long half-life in circulation
- Enterohepatic circulation of Thyroid hormones
- Liver as major site of degradation of Thyroid hormones
Dosage & Administration
- Adult dose initial starting dose: 25-50 mcg/day
- Pediatric dosage starting dose: 10-15 mcg/kg/day
- Gradual increments in dose at 6-8 week intervals
- Adjustments based on clinical response and laboratory parameters
Interaction
- Concurrent use of tri/tetracyclic antidepressants and Thyrin
- Administration of sertraline in patients stabilized on Thyrin
- Addition of Thyrin to antidiabetic or insulin therapy
- Careful monitoring of diabetic control
Contraindications
- Untreated subclinical or overt Thyrotoxicosis
- Acute Myocardial Infarction
- Uncorrected Adrenal failure
Side Effects
- Adverse reactions associated with Thyrin therapy
- Range of effects on general, central nervous system, musculoskeletal, cardiovascular, respiratory, gastrointestinal, and dermatologic
Pregnancy & Lactation
- Pregnancy Category A
- Increase in Levothyroxine requirements during pregnancy
- Caution in administration to nursing women
Precautions & Warnings
- Treat adrenocortical insufficiency before starting Thyrin therapy
- Careful dose selection in patients with cardiovascular disease
- Adjustment of dosage with marked change in body weight
- Monitoring blood levels of T3 and T4
- Establishing correct dosage by monitoring serum level of TSH
Overdose Effects
- Signs and symptoms of hyperthyroidism
- Cerebral embolism, shock, coma, and death reported
- Reducing or temporarily discontinuing dose if signs of overdosage occur
- Symptomatic treatment
Therapeutic Class
- Thyroid drugs & hormone
Storage Conditions
- Store below 30°C in a dry place
- Protect from light
- Keep out of the reach of children