Demax 0.5 mg (Tablet)

Unit Price: ৳ 1.00 (100's pack: ৳ 100.00)

Medicine Details

Category	Details
Generic	Dexamethasone
Company	Medimet pharmaceuticals ltd
Also available as	Demax 5 mg injection Dexam 5 mg injection Dexam 05 mg tablet

Indications

Severe or incapacitating allergic conditions in asthma
Atopic dermatitis control
Contact dermatitis treatment
Drug hypersensitivity reactions management
Perennial or seasonal allergic rhinitis control
Serum sickness treatment
Collagen disease control like lupus erythematosus and rheumatoid arthritis
Dermatologic diseases management such as pemphigus and severe erythema multiforme
Endocrine disorders treatment including primary or secondary adrenocortical insufficiency
Gastrointestinal diseases control like regional enteritis and ulcerative colitis
Hematologic disorders management for acquired hemolytic anemia and idiopathic thrombocytopenic purpura
Neoplastic diseases treatment for leukemias and lymphomas
Nervous system control in acute exacerbations of multiple sclerosis and cerebral edema
Ophthalmic diseases management for temporal arteritis and uveitis
Renal diseases treatment for idiopathic nephrotic syndrome
Respiratory diseases control including berylliosis and symptomatic sarcoidosis
Rheumatic disorders management for acute gouty arthritis and rheumatoid arthritis
Diagnostic testing for adrenocortical hyperfunction
Treatment for trichinosis with neurologic or myocardial involvement
Management of tuberculous meningitis with subarachnoid block or impending block

Pharmacology

Synthetic glucocorticoid decreasing inflammation by inhibiting leukocyte migration and reversing increased capillary permeability. Suppresses normal immune response.

Dosage & Administration

Tablet Dosage:
- Daily oral dosages vary from 1 mg to 10 mg for adults
- Children's dosage varies from 0.03-0.20 mg/kg body weight
Injection Administration:
- Intravenous (IV), intramuscular (IM), or local injection
- Intravenous injections of massive doses given slowly over several minutes
- Intra-articular injections given under strictly aseptic conditions

Interactions

Diuretics and/or cardiac glycosides
Antidiabetics
Non-steroidal anti-inflammatory drugs
Oral anticoagulants
Liver enzyme inducing drugs
Salicylates
Antacids

Contraindications

Gastric and duodenal ulcers
Systemic and ophthalmic fungal infections
Viral infections
Glaucoma
Hypersensitivity to corticosteroids

Side Effects

Endocrine and Metabolic Disturbances: Cushing-like syndrome, hirsutism, menstrual irregularities, premature epiphyseal closure
Fluid and Electrolyte Disturbances: Sodium and fluid retention, potassium loss, hypokalaemic alkalosis
Musculo-skeletal Effects: Myopathy, abdominal distension, osteoporosis
Gastro-intestinal Effects: Gastric and duodenal ulceration, perforation, haemorrhage
Dermatological Effects: Impaired wound healing, skin atrophy, striae, increased sweating, acne
Central Nervous System Effects: Psychic disturbances, convulsions, pseudotumor cerebri in children
Ophthalmic Effects: Glaucoma, increased intraocular pressure, posterior subcapsular cataracts
Immunosuppressive Effects: Increased susceptibility to infections, decreased responsiveness to vaccination and skin tests

Pregnancy & Lactation

Category C - Use only if potential benefit justifies potential risk to fetus. Glucocorticoids appear in breast milk, caution advised for breastfeeding mothers.

Precautions & Warnings

General: Use lowest possible dose, reduce dosage gradually
Cardio-renal: Caution in patients with heart failure, hypertension, or renal insufficiency
Endocrine: Minimize drug-induced secondary adrenocortical insufficiency by gradual reduction of dosage
Gastrointestinal: Use with caution in peptic ulcers, diverticulitis, and ulcerative colitis
Musculoskeletal: Consider osteoporosis risk before initiation of therapy
Neuro-psychiatric: Watch for acute myopathy with high doses, monitor for psychic disturbances

Use in Special Populations

Pediatric patients should be titrated to the lowest effective dose to minimize potential growth effects