Dexison 0.5 mg (Tablet)
Unit Price: ৳ 0.90 (100's pack: ৳ 90.01)
Medicine Details
| Category | Details |
|---|---|
| Generic | Dexamethasone |
| Company | Edruc limited |
Indications
- Severe allergic conditions in asthma
- Atopic dermatitis
- Contact dermatitis
- Drug hypersensitivity reactions
- Perennial allergic rhinitis
- Seasonal allergic rhinitis
- Serum sickness
- Collagen diseases like lupus erythematosus, rheumatoid arthritis
- Dermatologic diseases such as bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome)
- Endocrine disorders like primary or secondary adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis
- Gastrointestinal diseases including regional enteritis, ulcerative colitis
- Hematologic disorders like acquired (autoimmune) hemolytic anemia, congenital (erythroid) hypoplastic anemia (Diamond-Blackfan anemia), idiopathic thrombocytopenic purpura in adults, selected cases of secondary thrombocytopenia
- Neoplastic diseases: Leukemias and lymphomas
- Nervous system: Acute exacerbations of multiple sclerosis, cerebral edema associated with brain tumor, craniotomy, head injury
- Ophthalmic diseases: Temporal arteritis, uveitis, ocular inflammatory conditions unresponsive to topical corticosteroids
- Renal diseases: Inducing diuresis, remission of proteinuria in idiopathic nephrotic syndrome, lupus erythematosus
- Respiratory diseases: Berylliosis, fulminating/disseminated pulmonary tuberculosis, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis
- Rheumatic disorders including acute gouty arthritis, acute rheumatic carditis, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, dermatomyositis, polymyositis, systemic lupus erythematosus
- Miscellaneous: Diagnostic testing of adrenocortical hyperfunction, trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block, impending block
Pharmacology
- Synthetic glucocorticoid
- Decreases inflammation by inhibiting leukocyte migration
- Reversal of capillary permeability increase
- Suppresses normal immune response
Dosage & Administration
- Oral dosages for adult patients ranging from 1 mg to 10 mg
- Oral dosages for children from 0.03-0.20 mg/kg body weight
- Higher temporary dosages may be needed in some patients
- Short dexamethasone suppression test
- Intravenous, intramuscular, or local injection administration
- Doses depend on severity of condition and patient's response
- Systemic therapy in adults typically requires daily doses of 0.05-0.20 mg/kg body weight
Interaction
- Interaction with diuretics and/or cardiac glycosides
- Interaction with antidiabetics
- Interaction with non-steroidal anti-inflammatory drugs
- Interaction with oral anti-coagulants
- Less effective when used with liver enzyme inducing drugs
- Interaction with salicylates
- Interaction with antacids
Contraindications
- Gastric and duodenal ulcers
- Systemic and ophthalmic fungal infections
- Viral infections (e.g. varicella, herpes genitalis)
- Glaucoma
- Hypersensitivity to corticosteroids
Side Effects
- Cushing-like syndrome
- Hirsutism
- Menstrual irregularities
- Decreased glucose tolerance
- Sodium and fluid retention
- Hypertension
- Muscle weakness
- Abdominal distension
- Gastric and duodenal ulceration
- Impaired wound healing
- Central nervous system effects
- Glaucoma
- Increased susceptibility to infections
Pregnancy & Lactation
- Pregnancy Category C
- Corticosteroids in breast milk
Precautions & Warnings
- Use lowest possible dose to control the condition
- Caution in patients with congestive heart failure, hypertension, or renal insufficiency
- Minimize secondary adrenocortical insufficiency via gradual dosage reduction
- Caution in active or latent peptic ulcers, diverticulitis, intestinal anastomoses, nonspecific ulcerative colitis
Use in Special Populations
- Minimize growth effects in pediatric patients
- Titrate to lowest effective dose
Overdose Effects
- Unlikely
- Supportive and symptomatic therapy
Storage Conditions
- Tablet: Store in cool & dry place, protected from light & moisture
- Injection: Store below 30°C, protected from light, do not freeze