Dextason 5 mg/ml (IM/IV Injection)
1 ml ampoule: ৳ 12.04 (2 x 5: ৳ 120.37)
Medicine Details
| Category | Details |
|---|---|
| Generic | Dexamethasone |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Indications
- Control of severe allergic conditions in asthma
- Management of dermatologic diseases like pemphigus
- Treatment of endocrine disorders such as adrenocortical insufficiency
- Management of neoplastic diseases like leukemias
- Treatment of nervous system conditions like multiple sclerosis exacerbations
- Inducing diuresis in renal diseases
- Adjunctive therapy for rheumatic disorders
- Diagnostic testing of adrenocortical hyperfunction
- Treatment of tuberculous meningitis
- Controlling allergic rhinitis
- Inhibiting migration of leukocytes to decrease inflammation
- Suppressed normal immune response
Pharmacology
- Synthetic glucocorticoid
- Inhibition of leukocyte migration
- Decreases capillary permeability
- Suppression of immune response
Dosage & Administration
- Oral dosages ranging from 1 mg to 10 mg in adults
- Intravenous, intramuscular, or local injections
- Variability in dexamethasone dosages based on severity
- Dosage tapering recommendations
- Specific dosage recommendations for systemic, emergency, and local therapy
- Administration protocols for injections
Interaction
- Potential interactions with diuretics and cardiac glycosides
- Impaired glucose tolerance with antidiabetics
- Increased gastrointestinal ulceration risk with NSAIDs
- Alteration of oral anticoagulant needs
- Effectiveness reduction with liver enzyme inducing drugs
- Cautionary guidance with concomitant salicylates and antacids
Contraindications
- Contradicted in gastric and duodenal ulcers
- Not recommended in fungal and viral infections
- Contraindicated in glaucoma
- Avoided in cases of hypersensitivity to corticosteroids
Side Effects
- Endocrine and metabolic disturbances like Cushing-like syndrome
- Fluid and electrolyte imbalances leading to hypertension
- Musculoskeletal effects such as myopathy
- Gastrointestinal effects including ulcers
- Dermatological effects like skin atrophy
- Psychic disturbances in the central nervous system
- Ophthalmic effects including glaucoma
- Immunosuppressive effects
Pregnancy & Lactation
- Pregnancy Category C
- Use in pregnant women justified by benefit-risk assessment
- Presence in breast milk with caution for breastfeeding mothers
Precautions & Warnings
- Lowest effective dose principle
- Caution in cardio-renal patients
- Attention in patients with endocrine disorders
- Gastrointestinal caution in peptic ulcers and colitis
- Musculoskeletal considerations for osteoporosis risks
- Neuro-psychiatric effects and precautions
Use in Special Populations
- Pediatric dose titration
- Minimizing growth effects of corticosteroids
Overdose Effects
- Unlikelihood of overdosage
- Treatment by symptomatic and supportive therapy
Storage Conditions
- Recommendations for tablet storage
- Injection storage guidelines