Steron 0.5 mg (Tablet)
Unit Price: ৳ 1.00 (10 x 10: ৳ 100.00)
Strip Price: ৳ 10.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Dexamethasone |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Control of severe allergic conditions in asthma
- Control of severe allergic conditions in atopic dermatitis
- Control of severe allergic conditions in contact dermatitis
- Control of severe allergic conditions in drug hypersensitivity reactions
- Control of severe allergic conditions in perennial allergic rhinitis
- Control of severe allergic conditions in seasonal allergic rhinitis
- Control of severe allergic conditions in serum sickness
- Control of collagen diseases like lupus erythematosus
- Control of collagen diseases like rheumatoid arthritis
- Control of dermatologic diseases like bullous dermatitis herpetiformis
- Control of dermatologic diseases like exfoliative erythroderma
- Control of dermatologic diseases like mycosis fungoides
- Control of dermatologic diseases like pemphigus
- Control of dermatologic diseases like severe erythema multiforme (Stevens-Johnson syndrome)
- Control of endocrine disorders like primary or secondary adrenocortical insufficiency
- Control of endocrine disorders like congenital adrenal hyperplasia
- Control of endocrine disorders like hypercalcemia associated with cancer
- Control of endocrine disorders like nonsuppurative thyroiditis
- Control of gastrointestinal diseases like regional enteritis
- Control of gastrointestinal diseases like ulcerative colitis
- Control of hematologic disorders like acquired (autoimmune) hemolytic anemia
- Control of hematologic disorders like congenital (erythroid) hypoplastic anemia
- Control of hematologic disorders like idiopathic thrombocytopenic purpura in adults
- Control of hematologic disorders like selected cases of secondary thrombocytopenia
- Control of neoplastic diseases like leukemias
- Control of neoplastic diseases like lymphomas
- Control of nervous system conditions like acute exacerbations of multiple sclerosis
- Control of nervous system conditions like cerebral edema associated with primary or metastatic brain tumor
- Control of nervous system conditions like craniotomy or head injury
- Control of ophthalmic diseases like temporal arteritis
- Control of ophthalmic diseases like uveitis
- Control of ophthalmic diseases like ocular inflammatory conditions unresponsive to topical corticosteroids
- Control of renal diseases to induce diuresis in idiopathic nephrotic syndrome
- Control of renal diseases to induce remission of proteinuria in idiopathic nephrotic syndrome
- Control of renal diseases to induce remission of proteinuria due to lupus erythematosus
- Control of respiratory diseases like berylliosis
- Control of respiratory diseases like fulminating or disseminated pulmonary tuberculosis
- Control of respiratory diseases like idiopathic eosinophilic pneumonias
- Control of respiratory diseases like symptomatic sarcoidosis
- Control of rheumatic disorders as adjunctive therapy for acute gouty arthritis
- Control of rheumatic disorders as adjunctive therapy for acute rheumatic carditis
- Control of rheumatic disorders as adjunctive therapy for ankylosing spondylitis
- Control of rheumatic disorders as adjunctive therapy for psoriatic arthritis
- Control of rheumatic disorders as adjunctive therapy for rheumatoid arthritis
- Control of rheumatic disorders as adjunctive therapy for dermatomyositis
- Control of rheumatic disorders as adjunctive therapy for polymyositis
- Control of rheumatic disorders as adjunctive therapy for systemic lupus erythematosus
- Diagnostic testing of adrenocortical hyperfunction
- Diagnostic testing of trichinosis with neurologic or myocardial involvement
- Diagnostic testing of tuberculous meningitis with subarachnoid block
Pharmacology
- Synthetic glucocorticoid
- Decreases inflammation by inhibiting migration of leukocytes
- Reversal of increased capillary permeability
- Suppresses normal immune response
Dosage & Administration
- Tablet dosages for adult patients range from 1 mg to 10 mg daily
- Tablet dosages for children range from 0.03-0.20 mg/kg body weight
- Short dexamethasone suppression test dosage: 1 mg at 11 p.m.
- Intravenous dexamethasone should be given slowly
- Intramuscular administration should be deep
- Intra-articular injections should be given under aseptic conditions
- Injection can be given by intravenous (IV), intramuscular (IM) or local injection
- Dexamethasone injections can be diluted with an infusion fluid
- Systemic therapy in adults: daily doses of 0.05-0.20 mg/kg body weight are usually sufficient
Interaction
- Enhanced potassium loss with diuretics and/or cardiac glycosides
- Impaired glucose tolerance with antidiabetics
- Increased incidence and/or severity of gastrointestinal ulceration with non-steroidal anti-inflammatory drugs
- Altered need for oral anti-coagulants
- Less effectiveness when used concomitantly with liver enzyme inducing drugs
- Potential risk of salicylate intoxication with long-term therapy concomitantly with glucocorticoids
- Impaired gastrointestinal absorption of glucocorticoids with certain antacids
Contraindications
- Gastric and duodenal ulcers
- Systemic and ophthalmic fungal infections
- Viral infections like varicella and herpes genitalis infections
- Viral infections of the eye
- Glaucoma
- Hypersensitivity to corticosteroids
Side Effects
- Cushing-like syndrome
- Hirsutism
- Menstrual irregularities
- Negative nitrogen and calcium balance
- Sodium and fluid retention
- Hypertension
- Myopathy
- Gastric and duodenal ulceration
- Impaired wound healing
- Psychic disturbances
- Increased susceptibility to infections
- Decreased responsiveness to vaccination and skin tests
Pregnancy & Lactation
- Pregnancy Category C
- Use during pregnancy only if potential benefit justifies potential risk to fetus
- Glucocorticoids appear in breast milk
- Mothers taking high dosages of corticosteroids advised not to breast-feed
Precautions & Warnings
- Use the lowest possible dose of corticosteroids to control the condition under treatment
- Caution in patients with congestive heart failure, hypertension, or renal insufficiency
- Minimize drug-induced secondary adrenocortical insufficiency by gradual reduction of dosage
- Use with caution in active or latent peptic ulcers, diverticulitis, intestinal anastomoses, and nonspecific ulcerative colitis
- Special consideration in patients at increased risk of osteoporosis before initiating corticosteroid therapy
Use in Special Populations
- To minimize potential growth effects of corticosteroids, pediatric patients should be titrated to the lowest effective dose
Overdose Effects
- Overdosage is unlikely
- Treatment is by supportive and symptomatic therapy
Storage Conditions
- Tablet: Store in a cool & dry place, protected from light & moisture
- Injection: Store below 30° C, protected from light, do not freeze, keep out of the reach of children