Kacin 500 mg/2 ml (IM/IV Injection)

2 ml ampoule: ৳ 60.00 (2 x 5: ৳ 600.00)

Medicine Details

Category Details
Generic Amikacin
Company Aci limited
Also available as
Kacin 100 mg injection Kacin 250 mg injection

Indications

  • Short-term treatment of serious Gram-negative bacterial infections
  • Effective in bacterial septicemia, respiratory tract infections, CNS infections, skin and soft tissue infections
  • Effective in intra-abdominal infections, burns, postoperative infections
  • Effective in complicated and recurrent urinary tract infections
  • Effective in staphylococci infections
  • May be considered as initial therapy in staphylococcal diseases

Pharmacology

  • Semi-synthetic aminoglycoside antibiotic
  • Active against pseudomonas, Escherichia coli, Proteus, Klebsiella, Acinetobacter, Citrobacter
  • Active against penicillinase and non-penicillinase-producing Staphylococcus species
  • Susceptible to strains resistant to other aminoglycosides

Dosage

  • 15 mg/kg/day in two equally-divided doses for adults and children
  • Neonates and premature children: initial loading dose of 10 mg/kg followed by 15 mg/kg/day
  • Elderly: dosage adjusted based on renal function assessment
  • Maximum adult dose: 1.5g/day, not to exceed 15g total
  • Impaired renal function: dose reduction and/or increased intervals between doses

Administration

  • Preferred intramuscular route for most infections
  • Intravenous route used for life-threatening infections or when intramuscular injection is not feasible
  • Intraperitoneal use as an irrigant in concentration of 0.25%

Interaction

  • Potentiation of myorelaxants' effects
  • Avoid concurrent administration with other aminoglycoside antibiotics
  • Increased risk of ototoxicity with fast-acting diuretics in renal failure patients
  • Increased risk of nephrotoxicity with Cephalosporins or Polymixins

Contraindications

  • Hypersensitivity to Amikacin or any constituents of the injection

Side Effects

  • Tinnitus
  • Vertigo
  • Reversible or irreversible deafness
  • Skin rash
  • Drug fever
  • Headache
  • Paraesthesia
  • Nausea
  • Vomiting

Pregnancy & Lactation

  • Potential risk of ototoxicity in fetus
  • No information available for safety during breastfeeding

Precautions & Warnings

  • Patients should be well hydrated to minimize renal tubule irritation
  • Treatment should be stopped if azotemia increases
  • Monitoring of renal function during aminoglycoside treatment is important

Use in Special Populations

  • Safety and effectiveness not established in children/adolescents under 16 years

Overdose Effects

  • Peritoneal dialysis or haemodialysis may aid in drug removal from blood

Therapeutic Class

  • Aminoglycosides

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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