Cortinex 100 mg/2 ml (IM/IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Hydrocortisone |
| Company | Ziska pharmaceuticals ltd |
Indications
- Primary or secondary adrenocortical insufficiency
- Acute adrenocortical insufficiency
- Shock unresponsive to conventional therapy
- Congenital adrenal hyperplasia
- Hypercalcemia associated with cancer
- Nonsuppurative thyroiditis
- Rheumatic Disorders
- Dermatologic Diseases
- Control of severe or incapacitating allergic conditions
- Ophthalmic Diseases
- Gastrointestinal Diseases
- Pulmonary tuberculosis
- Loeffler's syndrome
- Hematologic Disorders
- Neoplastic Diseases
- Edematous States
- Acute exacerbations of multiple sclerosis
Pharmacology
Hydrocortisone inhibits prostaglandin synthesis by inhibiting the enzyme phospholipase A2. It reduces various vasoactive agents released during inflammation and controls the rate of protein synthesis.
Dosage & Administration
- Initial dosage of 20 mg to 240 mg of hydrocortisone per day
- Variable dosage requirements
- Individualized dosage based on disease and patient response
- Maintenance dosage determination
- Constant monitoring needed
- Gradual withdrawal recommended for long-term therapy
- Adult injection dosage range: 100 mg to 500 mg
- Children injection dosage: 25 mg (up to 1 year), 50 mg (1-5 years), 100 mg (6-12 years)
Interaction
Drugs that induce hepatic enzymes may increase the clearance of corticosteroids. Drugs such as Troleandomycin and Ketoconazole may inhibit the metabolism of corticosteroids and decrease their clearance. Corticosteroid dose should be titrated to avoid steroid toxicity.
Contraindications
Contraindicated in severe systemic fungal infections and patients with known hypersensitivity to any component of this product
Side Effects
- Cardiac arrhythmia
- Esophageal candidiasis
- Menstrual irregularity
- Decreased carbohydrate & glucose tolerance
- Fluid retention
- Increased appetite
- Weight gain
- Euphoria
- Mood swings
- Depression
- Insomnia
- Acne
Pregnancy & Lactation
Prescribed in pregnancy and lactation only if absolutely required
Precautions & Warnings
- Used with caution in patients with a history of peptic ulceration
- Increased incidence of peptic ulceration
- Used with caution in patients with congestive heart failure, hypertension, glaucoma, diabetes mellitus, and epilepsy
Therapeutic Class
Glucocorticoids
Storage Conditions
Keep below 30°C temperature, away from light & moisture, and out of the reach of children