Cortan 10 mg (Tablet)
Unit Price: ৳ 3.23 (10 x 10: ৳ 323.00)
Strip Price: ৳ 32.30
Medicine Details
| Category | Details |
|---|---|
| Generic | Prednisolone |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Title
- Cortan
Categories
- Medicine
- Pharmaceutical
Description
- Synthetic adrenocortical drug
- Glucocorticoid properties
- Inhibits phospholipase A2 enzyme
- Reduces inflammatory mediators production
- Rapid absorption from gastrointestinal tract
- Metabolized in the liver
- Excreted in urine
- Used for Rheumatic Disorders, Endocrine Disorders, Dermatologic Diseases, Allergic States, Respiratory Diseases, Hematologic Disorders, Edematous States, Gastrointestinal Diseases, and more
- Reduces potassium levels in the blood
- Possible adverse effects on skin color, dizziness, flushing, sweating, and lightheadedness
- Not recommended during pregnancy
- Caution in diabetes, hypertension, psychological disturbances, osteoporosis, chronic nephritis
- Potential risk for Cushing's habitus, hyperglycemia, muscular weakness, increased susceptibility to infection, delayed wound healing, and psychiatric disturbances
- Cool and dry storage
- Protected from light
- Keep out of reach of children
Indications
- Psoriatic arthritis
- Rheumatoid arthritis
- Juvenile rheumatoid arthritis
- Ankylosing spondylitis
- Acute and subacute bursitis
- Acute nonspecific tenosynovitis
- Acute gouty arthritis
- Post-traumatic osteoarthritis
- Primary or secondary adrenocortical insufficiency
- Congenital adrenal hyperplasia
- Nonsuppurative thyroiditis
- Hypercalcemia associated with cancer
- Pemphigus
- Bullous dermatitis herpetiformis
- Severe erythema multiforme
- Exfoliative dermatitis
- Mycosis fungoides
- Severe psoriasis
- Seasonal or perennial allergic rhinitis
- Bronchial asthma
- Contact dermatitis
- Atopic dermatitis
- Serum sickness
- Drug hypersensitivity reactions
- Symptomatic sarcoidosis
- Berylliosis
- Fulminating aspiration pneumonitis
- Idiopathic thrombocytopenic purpura
- Ulcerative colitis
- Regional enteritis
Pharmacology
- Synthetic adrenocortical drug
- Predominantly glucocorticoid properties
- Inhibits action of phospholipase A2 enzyme
- Reduces production of inflammatory mediators like Leukotrienes, SRS-A, Prostaglandins
- Rapid and well absorbed from gastrointestinal tract
- 70-90% protein-bound in plasma
- Eliminated from plasma with a half-life of 2 to 4 hours
- Metabolized mainly in the liver
- Excreted in the urine
Dosage & Administration
- Adult nephrotic syndrome initial dose: 2 mg/kg/day (maximum 80 mg/day)
- Adult maintenance dose: 0.5 to 1 mg/kg/dose given every other day for 3 to 6 months
- Anti-inflammatory dose: 5 to 60 mg per day in divided doses 1 to 4 times/day
- Acute asthma dose: 40-60 mg/day PO in single daily dose or divided q12 hr for 3-10 days
- Pediatric asthma dose varies by age
Interaction
- Reduced efficacy with Aminoglutethimide, Antacids, Barbiturates, Carbamazepine, Griseofulvin, Mitotane, Phenylbutazone, Phenytoin, Primidone, and Rifampin
- Reduces potassium in the blood
- Potential adverse interactions with Digitalis and immunizations
Contraindications
- Systemic infections without specific anti-infective therapy
- Hypersensitivity to any ingredient
- Ocular herpes simplex
Side Effects
- Increased appetite
- Indigestion
- Nervousness or restlessness
- Darkening or lightening of skin color
- Dizziness or lightheadedness
- Flushing of face or cheeks
- Hiccups
- Increased sweating
- Sensation of spinning
Pregnancy & Lactation
- Not recommended during pregnancy unless essential
- Caution during lactation due to potential effects on breast milk
Precautions & Warnings
- Caution in diabetes, hypertension, psychological disturbances, osteoporosis, post-menopausal women, pregnancy, and chronic nephritis
- Long-term use can lead to Cushing's habitus, hyperglycemia, muscular weakness, increased susceptibility to infection, delayed wound healing, and psychiatric disturbances
Overdose Effects
- Adverse effects develop after prolonged use of excess doses
- Treatment is symptomatic
Therapeutic Class
- Glucocorticoids
Storage Conditions
- Cool and dry
- Protected from light
- Keep out of reach of children