Delta 5 mg (Tablet)

Unit Price: ৳ 0.70 (500's pack: ৳ 350.00)

Medicine Details

Category	Details
Generic	Prednisolone
Company	Bristol pharmaceuticals ltd

Indications

Rheumatic Disorders
Endocrine Disorders
Dermatologic Diseases
Allergic States
Respiratory Diseases
Hematologic Disorders
Edematous States
Gastrointestinal Diseases

Pharmacology

Prednisolone is a synthetic adrenocortical drug with predominantly glucocorticoid properties. It directly inhibits the action of the Phospholipase A2 enzyme responsible for the production of inflammatory mediators. It is rapidly absorbed from the gastrointestinal tract, 70-90% protein-bound in the plasma, with a half-life of 2 to 4 hours.

Dosage & Administration

Adult:
- Nephrotic Syndrome:
  - Initial: 2 mg/kg/day (max 80 mg/day) in divided doses 3-4 times/day
  - Maintenance: 0.5-1 mg/kg/dose every other day for 3-6 months
- Anti-inflammatory: 5-60 mg/day in divided doses 1-4 times/day
- Acute Asthma: 40-60 mg/day PO in single daily dose or divided q12 hr for 3-10 days
- Allergic Conditions:
  - Day 1-6 regimen for adults
- Pediatric:
  - Asthma:
    - 1-4 years: Acute- 20 mg orally every 12 hours, Maintenance- 20 mg orally every other day
    - 12 years: Acute- 40 mg orally every 12 hours, Maintenance- 40 mg orally every other day
  - Anti-inflammatory: 0.05-2 mg/kg/day divided 1-4 times/day
  - Immunosuppression: 0.05-2 mg/kg/day divided 1-4 times/day

Interaction

Efficacy reduced by Aminoglutethimide, Antacids, Barbiturates, Carbamazepine, Griseofulvin, Mitotane, Phenylbutazone, Phenytoin, Primidone and Rifampin. Decreases blood potassium. Digitalis can cause Cardiac arrhythmias if hypokalemia occurs. Immunization should be done carefully.

Contraindications

Systemic infections without specific anti-infective therapy, Hypersensitivity to any ingredient, Ocular herpes simplex

Side Effects

Increased appetite
Indigestion
Nervousness or restlessness
Darkening or lightening of skin color
Dizziness or lightheadedness
Flushing of face or cheeks
Hiccups
Increased sweating
Sensation of spinning

Pregnancy & Lactation

Not recommended during pregnancy unless essential. Should only be used if expected benefit to the mother is greater than any possible risk to the foetus. Appears in breast milk and could suppress growth or cause unwanted effects.

Precautions & Warnings

Precaution in diabetes, hypertension, Psychological disturbances, osteoporosis, post-menopausal women, pregnancy, chronic nephritis. Long-term use can cause Cushing's habitus, hyperglycemia, muscular weakness, increased susceptibility to infection, delayed wound healing, psychiatric disturbances.

Overdose Effects

Adverse effects develop after prolonged use of excessive doses. Treatment is symptomatic, and the dose should be reduced gradually where possible.

Therapeutic Class

Glucocorticoids

Storage Conditions

Store in a cool and dry place, protected from light. Keep out of the reach of children.