Deltapred 10 mg (Tablet)

Unit Price: ৳ 2.00 (10 x 10: ৳ 200.00)
Strip Price: ৳ 20.00

Medicine Details

Category Details
Generic Prednisolone
Company Ziska pharmaceuticals ltd
Also available as
Deltapred 5 mg tablet Pedipred 5 mg oral solution

Title

Deltapred

Categories

  • Medicine
  • Pharmaceutical
  • Glucocorticoid

Description

A synthetic adrenocortical drug used in the treatment of various conditions such as rheumatic disorders, endocrine disorders, dermatologic diseases, allergic states, respiratory diseases, hematologic disorders, edematous states, gastrointestinal diseases, nephrotic syndrome, asthma, and immunosuppression.

Indications

  • Psoriatic arthritis
  • Rheumatoid arthritis
  • Juvenile rheumatoid arthritis
  • Ankylosing spondylitis
  • Acute and subacute bursitis
  • Acute nonspecific tenosynovitis
  • Acute gouty arthritis
  • Post-traumatic osteoarthritis
  • Primary or secondary adrenocortical insufficiency
  • Congenital adrenal hyperplasia
  • Nonsuppurative thyroiditis
  • Hypercalcemia associated with cancer
  • Pemphigus
  • Bullous dermatitis herpetiformis
  • Severe erythema multiforme
  • Exfoliative dermatitis
  • Mycosis fungoides
  • Severe psoriasis
  • Seasonal or perennial allergic rhinitis
  • Bronchial asthma
  • Contact dermatitis
  • Atopic dermatitis
  • Symptomatic sarcoidosis
  • Berylliosis
  • Fulminating aspiration pneumonitis
  • Idiopathic thrombocytopenic purpura
  • Secondary thrombocytopenia
  • Acquired (autoimmune) hemolytic anemia
  • Erythroblastopenia (RBC anemia)
  • To induce diuresis
  • Remission of proteinuria in nephrotic syndrome
  • Ulcerative colitis
  • Regional enteritis

Pharmacology

Prednisolone is a synthetic adrenocortical drug with predominantly glucocorticoid properties. It inhibits the action of the Phospholipase A2 enzyme responsible for producing inflammatory mediators. Well absorbed from the gastrointestinal tract with a half-life of 2 to 4 hours. Metabolized in the liver and excreted in the urine.

DosageAndAdministration

  • Adult:
    • NephroticSyndrome: 2 mg/kg/day in divided doses; maintenance: 0.5 to 1 mg/kg every other day
    • Anti-inflammatory: 5 to 60 mg per day in divided doses
    • AcuteAsthma: 40-60 mg/day PO in single daily dose or divided q12 hr for 3-10 days
    • AllergicConditions: Gradual tapering from 10 mg to 5 mg over 6 days
  • Pediatric:
    • Asthma: 10-40 mg orally every 12 hours depending on age
    • Anti-inflammatory: 0.05 to 2 mg/kg/day divided 1 to 4 times/day
    • Immunosuppression: 0.05 to 2 mg/kg/day divided 1 to 4 times/day

Interaction

  • ReducesEfficacy:
    • Aminoglutethimide
    • Antacids
    • Barbiturates
    • Carbamazepine
    • Griseofulvin
    • Mitotane
    • Phenylbutazone
    • Phenytoin
    • Primidone
    • Rifampin
  • ReducesPotassium: Deltapred
  • PotentiallyHarmfulInteraction: Digitalis with hypokalemia

Contraindications

Systemic infections, hypersensitivity to any ingredient, ocular herpes simplex

SideEffects

  • Common:
    • Increased appetite
    • Indigestion
    • Nervousness or restlessness
  • LessFrequentOrRare:
    • Skin color changes
    • Dizziness or lightheadedness
    • Flushing of face or cheeks
    • Hiccups
    • Increased sweating
    • Sensation of spinning

PregnancyAndLactation

  • Pregnancy: Not recommended unless essential
  • Lactation: May suppress growth, interfere with endogenous corticosteroid production

PrecautionsAndWarnings

Caution in diabetes, hypertension, psychological disturbances, osteoporosis, pregnancy, chronic nephritis. Long-term use can cause Cushing's habitus, hyperglycemia, muscular weakness, increased susceptibility to infection, delayed wound healing, psychiatric disturbances.

OverdoseEffects

Adverse effects develop after prolonged use of excessive doses. Treatment is symptomatic with gradual dose reduction.

TherapeuticClass

Glucocorticoids

StorageConditions

Store in a cool and dry place, protected from light. Keep out of the reach of children

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