Solone 5 mg (Tablet)

Unit Price: ৳ 1.72 (10 x 10: ৳ 172.00)

Strip Price: ৳ 17.20

Medicine Details

Category	Details
Generic	Prednisolone
Company	Aci limited
Also available as	Solone 10 mg tablet Solone 20 mg tablet Solone 5 mg oral solution

Title

Solone Tablets

Description

Solone Tablets are indicated for various conditions including rheumatic disorders, endocrine disorders, dermatologic diseases, allergic states, respiratory diseases, hematologic disorders, edematous states, gastrointestinal diseases, and more. The tablets have glucocorticoid properties and are primarily used for anti-inflammatory purposes. The dosage and administration vary for adults and pediatrics depending on the specific condition being treated. The medicine has interactions with certain other drugs and has contraindications in cases of systemic infections, hypersensitivity, and ocular herpes simplex. It may cause side effects such as increased appetite, indigestion, nervousness, skin color changes, dizziness, flushing, hiccups, increased sweating, and more. Precautions need to be taken during pregnancy, lactation, and in patients with diabetes, hypertension, psychological disturbances, osteoporosis, chronic nephritis, and more. Storage conditions require keeping the tablets in a cool, dry place protected from light and out of reach of children.

Brand

Solone

Formulation

Tablet

Pack Size

10 tablets per strip

Manufacturer

Square Pharmaceuticals Ltd.

Generic Name

Prednisolone

Pharmacology

Synthetic adrenocortical drug with predominantly glucocorticoid properties. Inhibits the action of the Phospholipase A2 enzyme responsible for producing inflammatory mediators. Rapidly and well absorbed from the gastrointestinal tract. Metabolized in the liver and excreted in the urine.

Indications

Psoriatic arthritis
Rheumatoid arthritis
Juvenile rheumatoid arthritis
Ankylosing spondylitis
Acute and subacute bursitis
Acute nonspecific tenosynovitis
Acute gouty arthritis
Post-traumatic osteoarthritis
Primary or secondary adrenocortical insufficiency
Congenital adrenal hyperplasia
Nonsuppurative thyroiditis
Hypercalcemia associated with cancer
Pemphigus
Bullous dermatitis herpetiformis
Severe erythema multiforme
Exfoliative dermatitis
Mycosis fungoides
Severe psoriasis
Seasonal or perennial allergic rhinitis
Bronchial asthma
Contact dermatitis
Atopic dermatitis
Serum sickness
Drug hypersensitivity reactions
Symptomatic sarcoidosis
Berylliosis
Fulminating aspiration pneumonitis
Idiopathic thrombocytopenic purpura
Secondary thrombocytopenia
Acquired (autoimmune) hemolytic anemia
Erythroblastopenia (RBC anemia)
To induce diuresis or remission of proteinuria in nephrotic syndrome
Ulcerative colitis
Regional enteritis

Dosage and Administration

Adult:
- Nephrotic Syndrome:
  - Initial: 2 mg/kg/day (maximum 80 mg/day) in divided doses 3 to 4 times/day until urine is protein free for 3 consecutive days (maximum: 28 days); followed by 1 to 1.5 mg/kg/dose given every other day for 4 weeks.
  - Maintenance dose: 0.5 to 1 mg/kg/ dose given every other day for 3 to 6 months.
- Anti-inflammatory: 5 to 60 mg per day in divided doses 1 to 4 times/day.
- Acute Asthma: 40-60 mg/day PO in single daily dose or divided q12 hr for 3-10 days.
- Allergic Conditions:
  - Day 1: 10 mg PO before breakfast, 5 mg after lunch and after dinner, and 10 mg at bedtime.
  - Day 2: 5 mg PO before breakfast, after lunch, and after dinner and 10 mg at bedtime.
  - Day 3: 5 mg PO before breakfast, after lunch, after dinner, and at bedtime.
  - Day 4: 5 mg PO before breakfast, after lunch, and at bedtime.
  - Day 5: 5 mg PO before breakfast and at bedtime.
  - Day 6: 5 mg PO before breakfast.
Pediatric:
- Asthma:
  - 1 year: Acute: 10 mg orally every 12 hours. Maintenance: 10 mg orally every other day.
  - 1 to 4 years: Acute: 20 mg orally every 12 hours. Maintenance: 20 mg orally every other day.
  - 5 to 12 years: Acute: 30 mg orally every 12 hours. Maintenance: 30 mg orally every other day.
  - 12 years: Acute: 40 mg orally every 12 hours. Maintenance: 40 mg orally every other day.
- Anti-inflammatory: 0.05 to 2 mg/kg/day divided 1 to 4 times/day.
- Immunosuppression: 0.05 to 2 mg/kg/day divided 1 to 4 times/day.

Interaction

Reduced Efficacy with:
- Aminoglutethimide
- Antacids
- Barbiturates
- Carbamazepine
- Griseofulvin
- Mitotane
- Phenylbutazone
- Phenytoin
- Primidone
- Rifampin
Reduction in Potassium Level with: Solone
Risk of Cardiac Arrhythmias with: Digitalis

Contraindications

Systemic infections unless specific anti-infective therapy is employed
Hypersensitivity to any ingredient
Ocular herpes simplex because of possible perforation

Side Effects

Common:
- Increased appetite
- Indigestion
- Nervousness or restlessness
Less frequent or rare:
- Darkening or lightening of skin color
- Dizziness or lightheadedness
- Flushing of face or cheeks
- Hiccups
- Increased sweating
- Sensation of spinning

Pregnancy and Lactation

Not recommended during pregnancy unless considered essential. May appear in breast milk and affect the infant.

Precautions and Warnings

Diabetes
Hypertension
Psychological disturbances
Osteoporosis
Post-menopausal women
Chronic nephritis

Overdose Effects

Adverse effects develop after prolonged use of doses above physiological requirement. Treatment is symptomatic and involves gradual dose reduction.