Solu-Medrol 1 gm/vial (IM/IV Injection)
1 gm vial: ৳ 2,810.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Methylprednisolone sodium succinate |
| Company | Pfizer |
| Also available as |
Title
- Solu-Medrol IM/IV
Category
- Medicine
- Pharmaceutical
- Healthcare
Indications
- Endocrine disorders
- Rheumatic disorders
- Collagen diseases
- Dermatological diseases
- Allergic states
- Ophthalmic diseases
- Gastrointestinal diseases
- Respiratory diseases
- Hematologic disorders
- Neoplastic diseases
- Edematous state
- Tuberculous meningitis
- Trichinosis
Pharmacology
- Naturally occurring glucocorticoid
- Salt-retaining properties
- Potent anti-inflammatory effects
- Excretion within 12 hours
- Influence on carbohydrate, protein, fat and purine metabolism
- Suppressive effect on the immune response
Dosage & Administration
- Administered by IM or IV
- High dose therapy
- Dosage variation based on clinical problem
- Gradual decrease or discontinuation of dosage
- Different initial dose for pediatric patients
- Specific dosage for the treatment of acute exacerbations of multiple sclerosis
Interaction
- Aminoglutethimide
- Amphotericin B injection and potassium-depleting agents
- Macrolide antibiotics
- Anticholinesterases
- Anticoagulants, oral
- Antidiabetics
- Antitubercular drugs
- Cholestyramine
- Cyclosporine
- Digitalis glycosides
- Estrogens, including oral contraceptives
- Hepatic Enzyme Inhibitors
- Ketoconazole
- Nonsteroidal anti-inflammatory agents (NSAIDs)
- Skin tests
- Vaccines
Contraindications
- Systemic fungal infections
- Known hypersensitivity
- Intrathecal administration
- Idiopathic thrombocytopenic purpura
Side Effects
- Fluid and electrolyte disturbances
- Musculoskeletal effects
- Gastrointestinal effects
- Dermatologic effects
- Neurological effects
- Endocrine effects
- Ophthalmic effects
- Others (Negative nitrogen balance)
Pregnancy & Lactation
- Teratogenic effects in many species
- No adequate and well-controlled studies in pregnant women
- Systemically administered corticosteroids in human milk
- Potential risk to the fetus
- Observation required for infants born to mothers who received corticosteroids
Precautions & Warnings
- Sensitive to heat
- Use lowest possible dose
- Gradual reduction in dosage
- Risk/benefit decision for dose and duration
- Complications dependent on dose and duration
- Observation for clinical improvement upon discontinuation
Use in Special Populations
- Similar adverse effects in pediatric patients and adults
- Decrease in growth velocity in pediatric patients
- Need for minimizing potential growth effects in pediatric patients
- Cautious dose selection for geriatric patients
Overdose Effects
- Supportive and symptomatic therapy
- Temporary reduction of corticosteroid dosage for chronic overdose
Therapeutic Class
- Glucocorticoids
Reconstitution
- Removal of protective plastic flip-of seal
- Cleansing stopper with suitable germicide
- Aseptic addition of Water for Injection BP
- Agitation for solution formation
- Injection withdrawal after solution formation
Storage Conditions
- Protection from light
- Controlled room temperature storage
- Usage within 48 hours after mixing