Solupred 500 mg/vial (IM/IV Injection)

500 mg vial: ৳ 600.00

Medicine Details

Category Details
Generic Methylprednisolone sodium succinate
Company Ziska pharmaceuticals ltd
Also available as
Solupred 1 gm injection Solupred 125 mg injection

Indications

  • Endocrine disorders
  • Rheumatic disorders
  • Collagen disease
  • Dermatological disease
  • Allergic states
  • Ophthalmic disease
  • Gastrointestinal disease
  • Respiratory disease
  • Hematologic disorder
  • Neoplastic disease
  • Edematous state
  • Tuberculous meningitis
  • Trichinosis

Pharmacology

  • Naturally occurring glucocorticoid
  • Potent anti-inflammatory effects
  • Salt-retaining properties
  • Intravenous injection effects
  • Excretion
  • Influences metabolism and electrolyte balance
  • Suppressive effect on the immune response

Dosage & Administration

  • Administered by IM or IV
  • High-dose therapy
  • Initial dosage variations
  • Administration for pediatric patients
  • Treatment of acute exacerbations of multiple sclerosis

Interaction

  • Aminoglutethimide
  • Amphotericin B injection and potassium-depleting agents
  • Macrolide antibiotics
  • Anticholinesterases
  • Anticoagulants, oral
  • Antidiabetics
  • Antitubercular drugs
  • Cholestyramine
  • Cyclosporine
  • Digitalis glycosides
  • Estrogens, including oral contraceptives
  • Hepatic Enzyme Inhibitors
  • Ketoconazole
  • Nonsteroidal anti-inflammatory agents (NSAIDs)
  • Skin tests
  • Vaccines

Contraindications

  • Systemic fungal infections
  • Hypersensitivity to the product and its constituents
  • Intrathecal administration
  • Idiopathic thrombocytopenic purpura

Side Effects

  • Fluid and electrolyte disturbances
  • Musculoskeletal effects
  • Gastrointestinal effects
  • Dermatologic effects
  • Neurological effects
  • Endocrine effects
  • Ophthalmic effects
  • Others
  • Adverse reactions related to parenteral corticosteroid therapy

Pregnancy & Lactation

  • Teratogenic potential
  • Corticosteroids in human milk
  • Observation for signs of hypoadrenalism in infants
  • Suppression of growth in infants

Precautions & Warnings

  • Sensitivity to heat
  • Gradual reduction in dosage
  • Risk/benefit decision for dose and duration of treatment
  • Complications dependent on dose and duration of treatment

Use in Special Populations

  • Adverse effects in pediatric patients
  • Decrease in growth velocity
  • Geriatric use considerations

Overdose Effects

  • Supportive and symptomatic therapy
  • Reduction of corticosteroid dosage

Therapeutic Class

  • Glucocorticoids

Reconstitution

  • Directions for reconstitution

Storage Conditions

  • Protect from light
  • Controlled room temperature storage
  • Use solution within 48 hours after mixing

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